Dennis E. Hallahan, MD, FASRO

Specialty Areas
Brain Tumors
Lymphoma
Lung Cancer
Sarcoma

Additional Features & Interviews with Dr. Hallahan:

Featured Physician

Press Release of Faculty Appointment

Areas of Clinical Interest
Brain tumors, cancer of the central nervous system, cancer antibody development, immunotherapy,

cancer drug development, radiation rrotecting drugs, nanoparticles, cancer drug delivery

gene therapy for cancer


Areas of Research Interest
Identification of new molecular targets for cancer therapy, drug development to improve cancer response to radiation therapy while minimizing the effect on normal tissues. Also drug development to protect tissues from radiation, antibody development and the use of nanoparticles for drug delivery


This physician is not able to accept new patients at this time.


Editorial Responsibilities for:

Journal of Clinical Oncology
Am Biomedical Engineering Journal
International Journal Radiation Biology
Am. J. Physiology
Journal National Cancer Inst.
Cancer Research
Intnl J Radiat Oncol Biol Phys
Radiation Research
Lymphoma and Leukemia
Radiation Oncology Investigations
Proc.Nat'l Acad Sci
Am J Resp Crit Care Medicine
Human Gene Therapy
EMBO
Gene Therapy
Cancer
Cancer Journal
Radiation Oncology Investigations

Selected Recent Publications:

Recent Books or Book Chapters

Miller SJ, Alam M, Andersen J, Berg D, Bichakjian CK, Bowen G, Cheney RT, Glass LF, Grekin RC, Hallahan DE. Et al Merkel Cell Carcinoma. NCCN Merkel Cell Carcinoma Panel. J Natl Compr Canc Netw; 7(3):322-32. March 2009

Roberto Diaz, Li Zhou, and Dennis E. Hallahan. The use of ionizing radiation for tumor targeted drug delivery. In: Targeted Delivery of Small and Macromolecular Drugs. (Ajit Narang & Ram Mahato, eds) 2009

Johnson, DH., Blot, W., Carbone, D., Gonzalez, A., Hallahan, D., Massion, P., Putnam, JB., Sandler, A. Cancer of the lung. In Abeloff’s Clinical Oncology (Eds. Abeloff, Armitage, Niederhuber, Kastan, McKenna) 2008

Roberto Diaz, Ralph J. Passarella, Dennis E. Hallahan. Determining Glioma Response to Radiation Therapy Using Recombinant Peptides. Expert Review of Anticancer Therapy. 8:1787 2008

Luigi Moretti, Sebahat Ocak, Dennis E. Hallahan and Bo Lu, Cell Cycle and Vascular Targets for Radiotherapy, Lung Cancer (Harvey Pass Ed.) Lippincott Williams & Wilkins, In Press, 2008

Luigi Moretti, Eddy S. Yang., Denis E. Hallahan., Bo Lu. Lithium as a Differential Neuroprotector during Brain Irradiation. In Press 2008

Jerry J. Jaboin, Zhaozhong Han, Dennis E. Hallahan, Radiation-Guided Drug Delivery of Radiosensitiziers. Gene Therapy of Cancer. In Press 2008

Reviewed Journal Articles

Kotipatruni RP, Ferraro DJ, Ren X, Vanderwaal RP, Thotala DK, Hallahan DE, Jaboin JJ.NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas. Integr Biol (Camb). 2012 Aug 7.

Jacobs KM, Bhave SR, Ferraro DJ, Jaboin JJ, Hallahan DE, Thotala D.GSK-3β: A Bifunctional Role in Cell Death Pathways. Int J Cell Biol. 2012;2012:930710.

Thotala DK, Hallahan DE, Yazlovitskaya EM.Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.
Cell Death Differ. 2012 Mar;19(3):387-96. doi: 10.1038/cdd.2011.94. Epub 2011 Jul 8.

Jarboe JS, Jaboin JJ, Anderson JC, Nowsheen S, Stanley JA, Naji F, Ruijtenbeek R, Tu T, Hallahan DE, Yang ES, Bonner JA, Willey CD.Kinomic profiling approach identifies Trk as a novel radiation modulator.Radiother Oncol. 2012 Jun;103(3):380-7.

Schleicher SM, Thotala DK, Linkous AG, Hu R, Leahy KM, Yazlovitskaya EM, Hallahan DE.
Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature. PLoS One. 2011;6(7):e22182.

Thotala DK, Hallahan DE, Yazlovitskaya EM.Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.
Cell Death Differ. 2012 Mar;19(3):387-96. doi: 10.1038/cdd.2011.94. Epub 2011 Jul 8.

Schulte RR, Linkous AG, Hallahan DE, Yazlovitskaya EM.Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer. Cancer Lett. 2011 May 28;304(2):137-43.

Hariri G, Wellons MS, Morris WH 3rd, Lukehart CM, Hallahan DE. Multifunctional FePt nanoparticles for radiation-guided targeting and imaging of cancer. Ann Biomed Eng. 2011 Mar;39(3):946-52. Epub 2010 Dec 4.

Lowery A, Onishko H, Hallahan DE, Han Z. Tumor-targeted delivery of liposome-encapsulated doxorubicin by use of a peptide that selectively binds to irradiated tumors.J Control Release. 2011 Feb 28;150(1):117-24. Epub 2010 Nov 12.

Hariri G, Yan H, Wang H, Han Z, Hallahan DE. Radiation-guided drug delivery to mouse models of lung cancer. Clin Cancer Res. 2010 Oct 15;16(20):4968-77. Epub 2010 Aug 27.

Linkous AG, Yazlovitskaya EM, Hallahan DE.Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst. 2010 Sep 22;102(18):1398-412.

Passarella RJ, Spratt DE, van der Ende AE, Phillips JG, Wu H, Sathiyakumar V, Zhou L, Hallahan DE, Harth E, Diaz R. Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors.Cancer Res. 2010 Jun 1;70(11):4550-9.

Hwang M, Hariri G, Lyshchik A, Hallahan DE, Fleischer AC.Correlation of quantified contrast-enhanced sonography with in vivo tumor response.J Ultrasound Med. 2010 Apr;29(4):597-607.

Passarella RJ, Zhou L, Phillips JG, Wu H, Hallahan DE, Diaz R. Recombinant Peptides as Biomarkers for Cancer Response to Molecular Targeted Therapy. Submitted, 2009 Clin Cancer Res. 2009 Oct 15;15(20):6421-9. Epub 2009 Oct 13.

Jaboin JJ, Han Z, Hallahan DE. Using in vivo biopanning for the development of radiation-guided drug delivery systems.Methods Mol Biol. 2009;542:285-300.

Miller SJ, Alam M, Andersen J, Berg D, Bichakjian CK, Bowen G, Cheney RT, Glass LF, Grekin RC, Hallahan DE, Kessinger A, Lee NY, Liegeois N, Lydiatt DD, Michalski J, Morrison WH, Nehal KS, Nelson KC, Nghiem P, Olencki T, Oseroff AR, Perlis CS, Rosenberg EW, Shaha AR, Urist MM, Wang LC; NCCN Merkel Cell Carcinoma Panel. Merkel cell carcinoma.J Natl Compr Canc Netw. 2009 Mar;7(3):322-32.

Linkous A, Geng L, Lyshchik A, Hallahan DE, Yazlovitskaya EM.  Cytosolic phospholipase A2: targeting cancer through the tumor vasculature.  Clin Cancer Res. 2009 Mar 1;15(5):1635-44. Epub 2009 Feb 24.

Yang, ES,  Hong Wang, Guochun Jiang, Allie Fu, Halahan, DE, Xia F. Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent nonhomologous end-joining of chromosomal break. J. Clinic Invest. 119(5):1124-35, 2009.

Jaboin JJ, Han Z, Hallahan DE. Using in vivo biopanning for the development of radiation-guided drug delivery systems. Methods Mol Biol. 542:285-300, 2009.

Han Z, Fu A, Wang H, Diaz R, Geng L, Onishko H, Hallahan DE.  Noninvasive assessment of cancer response to therapy.Nat Med. 2008 Mar;14(3):343-9. Epub 2008 Feb 24.

Ghazal Hariri, Ying Zhang; Zhaozhong Han; Allie Fu; Martin Brechbiel; Noor Tantawy; Todd Peterson, Hallahan, Dennis. Radiation-guided P-selectin targeted tumor imaging in a lung tumor model. Annals of Biomedical Engineering, 36(5):821-30, 2008

Huamani J, Willey C, Thotala D, Niermann KJ, Reyzer M, Leavitt L, Jones C, Fleishcher A, Caprioli R, Hallahan DE, Kim DW. Differential efficacy of combined therapy with radiation and AEE788 in high and low EGFR-expressing androgen-independent prostate tumor models.  Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):237-46. Epub 2008 Mar 11.

Tianxiang Tu, Dinesh Thotala, Ling Geng, Dennis E. Hallahan, Christopher D. Willey. BMX is activated by ionizing radiation and is a molecular target for development for radiosensitizing drugs. Cancer Research, 68(8):2861–9, 2008

Cuneo KC, Geng L, Fu A, Orton D, Hallahan DE, Chakravarthy AB. SU11248 (Sunitinib) Sensitizes Pancreatic Cancer to the Cytotoxic Effects of Ionizing Radiation. Int J Radiat Oncol Biol Phys. 71(3):873-9. 2008

Li, Xia; Jessica Huamani, Lyshchik, Andrej; Benoit Dawant; Hallahan, Dennis; Gore, John C; Yankeelov, Thomas. A Method for Assessing Tumor Microvasculature in a Murine Tumor Model using Contrast Enhanced Ultrasound. Journal of Ultrasound in Medicine 2008

Loveless ME, Li X, Huamani J, Lyshchik A, Dawant B, Hallahan D, Gore JC, Yankeelov TE. Method for Assessing the Microvasculature in a Murine Tumor Model Using Contrast-Enhanced Ultrasonography. J Ultrasound Med.;27:1699-1709, 2008

Yazlovetzkaya E., Linkous, A., Thotala, D., Hallahan, DE. Phospholipase A2 in cell viability. Cell Death and Differentiation, 15(10):1641-53, 2008

Thotala, D. Linkous, A; Hallahan,DE. Yazlovetzkaya E. Inhibition of glycogen synthase kinase 3? attenuates neuronal progenitor cell death in the irradiated brain. Cancer Research, 68: 5859-5868, 2008

Hallahan, DE., Han, Z. Selection of Phage-displayed peptides that bind to cancer following treatment. Nature Protocols, Published Online, 2008 http://www.natureprotocols.com/2008/02/27/selection_of_phagedisplayed_pe.php

Han, Z, Fu, A., Diaz, R, Wang, Onishko, Hallahan, DE. Rapid Assessment of cancer responsiveness to TKIs. Nature Medicine, 14: 343 - 349, 2008

Radiation Oncology

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Cancer Center (Siteman Cancer Center)

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Health Insurance Plans Accepted

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