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Pediatrics

Jeffrey J. Bednarski, II, MD

Current Position
Instructor, Pediatrics
Division of Hematology and Oncology


Specialty Areas
Pediatric Hematology
Pediatric Oncology

Patients Seen At
St. Louis Children's Hospital
One Children's Place, Suite 9S, 9 Floor
St. Louis, MO  63110
314-454-6018
314-454-2780
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Pediatrics
660 South Euclid Avenue, Campus Box 8116
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric cancer, pediatric hematology, pediatric oncology, pediatric brain tumors. 

Areas of Research Interest
Cellular responses to DNA damage in lymphocytes and the connection of these responses to immune development.

Board Certification
Pediatrics -- Certified
Pediatric Hematology/Oncology

Medical Education
B.S.: Chemistry, Duke University, Durham, North Carolina, 1995
Medical Degree: University of Michigan Medical School, Ann Arbor, Michigan, 2003
Ph.D.: University of Michigan Medical School, Ann Arbor, Michigan, 2003
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri, 2006
Fellowship: Pediatric Hematology-Oncology, Washington University School of Medicine, St. Louis, Missouri, 2009
Hospital Affiliations
St. Louis Children's Hospital

Honors and Awards
David Gilstrap Memorial Award, St. Louis Children's Hospital, St. Louis, MO 2008

James P. Keating Outstanding Resident Award, St. Louis Children's Hospital, St. Louis, MO 2005

Regent's Fellowship, University of Michigan Rackham Graduate School, 1997-2001

Recent or Selected Journal Articles
Steinel NC, Lee BS, Tubbs AT, Bednarski JJ, Schulte E, Yang-Iott KS, Schatz DG, Sleckman BP, Bassing CH. The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. J Exp Med. 2013 Feb 11;210(2):233-9.

Bednarski JJ, Sleckman BP. Lymphocyte development: integration of DNA damage response signaling. Adv Immunol. 2012;116:175-204.

Bednarski JJ, Sleckman BP. Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle. 2012 Nov 15;11(22):4129-34.

Bednarski JJ, Nickless A, Bhattacharya D, Amin RH, Schlissel MS, Sleckman BP. RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med. 2012 Jan 16;209(1):11-7.

Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2022-7.

Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP. H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature. 2011 Jan 13;469(7329):245-9.

Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee Wl, Pandita TK, Bassing CH, Sleckman BP. Mre11/Rad50/Nbs1 functions in the non-homologous end-joining of Rag-mediated DNA double strand breaks. J Exp Med 2006:669-679 (2009)

Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med. 2009 Mar 16;206(3):669-79.

Bednarski JJ, Lyssiotis CA, Roush R, Boitano AE, Glick GD, Opipari AW Jr. A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis. J Biol Chem. 2004 Jul 9;279(28):29615-21. Epub 2004 May 3.

Fleming JC, Tartaglini E, Kawatsuji R, Yao D, Fujiwara Y, Bednarski JJ, Fleming MD, Neufeld EJ. Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. Mol Genet Metab. 2003 Sep-Oct; 80(1-2): 234-41.

Bednarski JJ, Warner RE, Rao T, Leonetti F, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW Jr, Glick GD. Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine. Arthritis Rheum. 2003 Mar;48(3):757-66.

Blatt NB, Bednarski JJ, Warner RE, Leonetti F, Johnson KM, Boitano A, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW Jr, Glick GD. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J Clin Invest. 2002 Oct;110(8):1123-32.

Chung SH, Song WJ, Kim K, Bednarski JJ, Chen J, Prestwich GD, Holz RW. The C2 domains of Rabphilin3A specifically bind phosphatidylinositol 4,5-bisphosphate containing vesicles in a Ca2+-dependent manner. In vitro characteristics and possible significance. J Biol Chem. 1998 Apr 24;273(17):10240-8.

Clementz T, Bednarski JJ, Raetz CR. Function of the htrB high temperature requirement gene of Escherchia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. J Biol Chem. 1996 May 17;271(20):12095-102.

Bednarski JJ, Nayduch DA. Thoracic aorta rupture as the cause of paraplegia: a diagnostic dilemma (case report). J Trauma. 1989 Apr;29(4):531-3.

Bednarski JJ, Warner RE, Rao T, Leonetti F, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Attenuation of autoimmune disease in fas-deficient mice with a cytotoxic benzodiazepine. Arthritis Rheum 48:757-766 (2003)

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Jeffrey J. Bednarski.

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Copyright 2014 Washington University School of Medicine