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Neurology / Adult

Marc I. Diamond, MD

Current Position
Associate Professor, Neurology
Division of Adult Neurology

Specialty Areas
Muscular Dystrophy
Huntington's Disease
Movement Disorders
Neurology - Adult

Patients Seen At
Center for Advanced Medicine
Neuroscience Center
4921 Parkview Place, Suite C, FL 6
St. Louis, MO  63110
Fax:   314-747-3258
View Floor Map  View Campus Map   View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Neurology
660 South Euclid Avenue, Campus Box 8111
St. Louis, Mo  63110

Areas of Clinical Interest
Neurodegenerative disease, polyglutamine disease, spinobulbar muscular atrophy, Huntington disease, prostate cancer, nuclear receptor function, regulation of protein folding, chemical/genetic screening, cell and molecular biology, neuroscience.

Board Certification
Neurology -- Certified

Medical Education
B.A.: History, Princeton University, Princeton, New Jersey, 1993
Medical Degree: UCSF School of Medicine, San Francisco, California, 1993
Residency: Neurology, UCSF School of Medicine, San Francisco, California, 1997
Chief Resident: Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 1997
Hospital Affiliations
Barnes-Jewish Hospital

Honors and Awards
Leadership Award, Huntington's Disease Society of America, 2007

Sandler Opportunity Award, 2007

Global Life Science Innovation Competition at UCSF Merck Research Laboratories prize for Innovation, First Prize; prize for Clinical Impact (runner-up); Overall competition (finalist).

Sandler Award for Innovation in Basic Science, 2002, 2005

Selected or Recent Journal Articles
Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH. Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. Hum Mol Genet. 2014 Jan 1;23(1):157-70.

Li M, Yasumura D, Ma AA, Matthes MT, Yang H, Nielson G, Huang Y, Szoka FC, Lavail MM, Diamond MI. Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PLoS One. 2013;8(2):e56026.

Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron. 2013 Oct 16;80(2):402-14.

Schindler SE, McConathy J, Ances BM, Diamond MI. Advances in diagnostic testing for Alzheimer disease. Mo Med. 2013 Sep-Oct;110(5):401-5. Review.

Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3138-47.

Kaufman SK, Diamond MI. Prion-like propagation of protein aggregation and related therapeutic strategies. Neurotherapeutics. 2013 Jul;10(3):371-82.

Zheng Z, Li A, Holmes BB, Marasa JC, Diamond MI. An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. J Biol Chem. 2013 Mar 1;288(9):6063-71.

Zheng Z, Diamond MI. Huntington disease and the huntingtin protein. Prog Mol Biol Transl Sci. 2012;107:189-214.

Shao J, Diamond MI. Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. PLoS One. 2012;7(3):e32802.

Holmes BB, Diamond MI. Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission? Ann Neurol. 2012 Dec;72(6):832-6.

Holmes BB, Diamond MI. Cellular mechanisms of protein aggregate propagation. Curr Opin Neurol. 2012 Dec;25(6):721-6.

Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI. Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem. 2012 Jun 1;287(23):19440-51.

Fuentealba RA, Marasa J, Diamond MI, Piwnica-Worms D, Weihl CC. An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. Hum Mol Genet. 2012 Feb 1;21(3):664-80.

Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011 Sep 14;31(37):13110-7.

Fuentealba RA, Udan M, Bell S, Wegorzewska I, Shao J, Diamond MI, Weihl CC, Baloh RH. Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43. J Biol Chem. 2010 Aug 20;285(34):26304-14.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Marc I. Diamond.

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Copyright 2014 Washington University School of Medicine