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Neurology / Pediatric

Christopher D. Smyser, MD

Current Position
Assistant Professor, Neurology
Division of Pediatric Neurology


Specialty Areas
Neonatal Neurology
Pediatric Stroke
Pediatric Neurology

Patients Seen At
St. Louis Children's Hospital
One Children's Place, Suite C/D, 2nd Floor
St. Louis, MO  63110
314-454-6120
Fax:   314-454-2523
View Driving Directions

Mailing Address
Department of Neurology
Washington University School of Medicine
660 South Euclid, Campus Box 8111
St. Louis, MO  63110

Areas of Clinical Interest
Neonatal neurology, pediatric stroke, cerebral palsy, CNS malformations, developmental disorders, general pediatric neurology.

Areas of Research Interest
Project mapping structural connections within and between systems in the neonatal brain through collection and analysis of functional connectivity MRI data (2007-current).

Board Certification
Pediatric Neurology -- Certified

Medical Education
B.S.: Biomedical Engineering, University of Iowa College of Medicine, Iowa City, IA, 1998
Medical Degree: University of Iowa College of Medicine, Iowa City, Iowa, 2004
Residency: Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, 2006
Chief Resident: Neurology, Washington University School of Medicine, St. Louis, Missouri, 2009
Residency: Child Neurology, Washington University School of Medicine/ St. Louis Children's Hospital, St. Louis, Missouri, 2009
Hospital Affiliations
St. Louis Children's Hospital

Professional Associations
Child Neurology Society, 2008-present
American Academy of Neurology, 2006-present

Honors and Awards
Steven M. Rothman Award for Outstanding Teaching by a Child Neurology Resident, Department of Neurology, Washington University School of Medicine, 2008

Selected or Recent Journal Articles
Al-Kateb H, Khanna G, Filges I, Hauser N, Grange DK, Shen J, Smyser CD, Kulkarni S, Shinawi M. Scoliosis and vertebral anomalies: Additional abnormal phenotypes associated with chromosome 16p11.2 rearrangement. Am J Med Genet A. 2014 May;164(5):1118-26.

Estep ME, Smyser CD, Anderson PJ, Ortinau CM, Wallendorf M, Katzman CS, Doyle LW, Thompson DK, Neil JJ, Inder TE, Shimony JS. Diffusion tractography and neuromotor outcome in very preterm children with white matter abnormalities. Pediatr Res. 2014 Apr 8.

Pineda RG, Neil J, Dierker D, Smyser CD, Wallendorf M, Kidokoro H, Reynolds LC, Walker S, Rogers C, Mathur AM, Van Essen DC, Inder T. Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments. J Pediatr. 2014 Jan;164(1):52-60.e2.

Lee MH, Smyser CD, Shimony JS. Resting-state fMRI: a review of methods and clinical applications. AJNR Am J Neuroradiol. 2013 Oct;34(10):1866-72.

Smyser CD, Snyder AZ, Shimony JS, Blazey TM, Inder TE, Neil JJ. Effects of white matter injury on resting state fMRI measures in prematurely born infants. PLoS One. 2013 Jul 9;8(7):e68098.

McDonell LM, Mirzaa GM, Alcantara D, Schwartzentruber J, Carter MT, Lee LJ, Clericuzio CL, Graham JM Jr, Morris-Rosendahl DJ, Polster T, Acsadi G, Townshend S, Williams S, Halbert A, Isidor B, David A, Smyser CD, Paciorkowski AR, Willing M, Woulfe J, Das S, Beaulieu CL, Marcadier J; FORGE Canada Consortium, Geraghty MT, Frey BJ, Majewski J, Bulman DE, Dobyns WB, O'Driscoll M, Boycott KM. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. Nat Genet. 2013 May;45(5):556-62.

Anderson JL, Levy PT, Leonard KB, Smyser CD, Tychsen L, Cole FS. Congenital Lymphocytic Choriomeningitis Virus: When to Consider the Diagnosis. J Child Neurol. 2013 May 10. [Epub ahead of print]

Smyser CD, Kidokoro H, Inder TE. Magnetic resonance imaging of the brain at term equivalent age in extremely premature neonates: to scan or not to scan? J Paediatr Child Health. 2012 Sep;48(9):794-800.

Mirzaa GM, Paciorkowski AR, Smyser CD, Willing MC, Lind AC, Dobyns WB. The microcephaly-capillary malformation syndrome. Am J Med Genet A. 2011 Sep;155A(9):2080-7.

Smyser CD, Snyder AZ, Neil JJ. Functional connectivity MRI in infants: exploration of the functional organization of the developing brain. Neuroimage. 2011 Jun 1;56(3):1437-52.

Smyser CD, Inder TE, Shimony JS, Hill JE, Degnan AJ, Snyder AZ, Neil JJ. Longitudinal analysis of neural network development in preterm infants. Cereb Cortex. 2010 Dec;20(12):2852-62

Smyser CD, Grabowski TJ, Rainville P, Bechara A, Razavi M, Mehta S, Eaton BL, Bolinger L.  Measurement, time-stamping, and analysis of electrodermal activity in fMRI.  Proceedings of the International Society of Optical Engineering (SPIE) 4683: 470-475, 2002.

Smyser CD, Grabowski TJ, Frank RJ, Haller J, Bolinger L.  A time-aware architecture for parametric analysis of fMRI data. Magnetic Resonance in Medicine 45(2): 289-298, 2001.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Christopher D. Smyser.

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Copyright 2014 Washington University School of Medicine