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Pediatrics

Joshua B. Rubin, MD, PhD

Current Position
Associate Professor, Pediatrics
Division of Hematology and Oncology
Co-Director, Pediatric Neuro-Oncology Center
St Louis Children's Hospital


Specialty Areas
Pediatric Hematology
Pediatric Oncology

Patients Seen At
St Louis Children's Hospital

One Children's Place, Suite 9, Floor 9 South
St. Louis, MO  63110
314-454-6018
Fax:   314-454-2780
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Pediatrics, Division of Hematology / Oncology
CB 8208, 660 S. Euclid Ave
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric hematology, pediatric oncology, brain tumor. optic glioma, neurofibromatosis

Areas of Research Interest
Neurobiology, specifically the role of CXCR4 in tumor-genesis in the CNS and the nature of the intracellular signals that support these functions.

Board Certification
Pediatric Hematology Oncology -- Certified
Pediatrics -- Certified

Medical Education
BS, Biology: Yale University, New Haven, CT, 1982
Masters of Science: Albert Einstein College of Medicine, New York, NY, 1992
Medical Degree: Albert Einstein College of Medicine, New York, NY, 1994
Ph D: Neuroscience, Albert Einstein College of Medicine, New York, NY, 1994
Hospital Affiliations
St. Louis Children's Hospital, St. Louis

Selected or Recent Journal Articles
Zhukova N, Ramaswamy V, Remke M, Pfaff E, Shih DJ, Martin DC, Castelo-Branco P, Baskin B, Ray PN, Bouffet E, von Bueren AO, Jones DT, Northcott PA, Kool M, Sturm D, Pugh TJ, Pomeroy SL, Cho YJ, Pietsch T, Gessi M, Rutkowski S, Bognar L, Klekner A, Cho BK, Kim SK, Wang KC, Eberhart CG, Fevre-Montange M, Fouladi M, French PJ, Kros M, Grajkowska WA, Gupta N, Weiss WA, Hauser P, Jabado N, Jouvet A, Jung S, Kumabe T, Lach B, Leonard JR, Rubin JB, Liau LM, Massimi L, Pollack IF, Shin Ra Y, Van Meir EG, Zitterbart K, Schüller U, Hill RM, Lindsey JC, Schwalbe EC, Bailey S, Ellison DW, Hawkins C, Malkin D, Clifford SC, Korshunov A, Pfister S, Taylor MD, Tabori U. Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma. J Clin Oncol. 2013 Jul 8. [Epub ahead of print]

Brooks MD, Sengupta R, Snyder SC, Rubin JB. Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche. Curr Pathobiol Rep. 2013 Jun 1;1(2):101-110.

Barone A, Rubin JB. Opportunities and challenges for successful use of bevacizumab in pediatrics. Front Oncol. 2013 Apr 29;3:92.

Patel JR, Williams JL, Muccigrosso MM, Liu L, Sun T, Rubin JB, Klein RS. Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS. Acta Neuropathol. 2012 Dec;124(6):847-60.

Johnson KJ, Fisher MJ, Listernick RL, North KN, Schorry EK, Viskochil D, Weinstein M, Rubin JB, Gutmann DH. Parent-of-origin in individuals with familial neurofibromatosis type 1 and optic pathway gliomas. Fam Cancer. 2012 Dec;11(4):653-6.

Sun T, Warrington NM, Rubin JB. Why does Jack, and not Jill, break his crown? Sex disparity in brain tumors. Biol Sex Differ. 2012 Jan 25;3:3.

Woerner BM, Luo J, Brown KR, Jackson E, Dahiya SM, Mischel P, Benovic JL, Piwnica-Worms D, Rubin JB. Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth. Mol Cancer Res. 2012 Jan;10(1):156-66.

Sengupta R, Dubuc A, Ward S, Yang L, Northcott P, Woerner BM, Kroll K, Luo J, Taylor MD, Wechsler-Reya RJ, Rubin JB. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Res. 2012 Jan 1;72(1):122-32.

Creach KM, Rubin JB, Leonard JR, Limbrick DD, Smyth MD, Dacey R, Rich KM, Dowling JL, Grubb RL Jr, Linette GP, King AA, Michalski JM, Park TS, Perry A, Simpson JR, Mansur DB. Oligodendrogliomas in children. J Neurooncol. 2012 Jan;106(2):377-82.

Rao S, Sengupta R, Choe EJ, Woerner BM, Jackson E, Sun T, Leonard J, Piwnica-Worms D, Rubin JB. CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma. PLoS One. 2012;7(3):e33005.

Perkins SM, Rubin JB, Leonard JR, Smyth MD, El Naqa I, Michalski JM, Simpson JR, Limbrick DL, Park TS, Mansur DB. Glioblastoma in children: a single-institution experience. Int J Radiat Oncol Biol Phys. 2011 Jul 15;80(4):1117-21.

Sengupta R, Sun T, Warrington NM, Rubin JB. Treating brain tumors with PDE4 inhibitors. Trends Pharmacol Sci. 2011 Jun;32(6):337-44.

Dorward IG, Luo J, Perry A, Gutmann DH, Mansur DB, Rubin JB, Leonard JR. Postoperative imaging surveillance in pediatric pilocytic astrocytomas. J Neurosurg Pediatr. 2010 Oct;6(4):346-52.

Goldhoff P, Rubin JB. Highlights from the latest articles in glioma immunotherapy. Immunotherapy. 2010 Jan;2(1):9-12.

Sun T, Gianino SM, Jackson E, Piwnica-Worms D, Gutmann DH, Rubin JB. CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice. J Neuroimmunol. 2010 Jul 27;224(1-2):108-13.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Joshua B. Rubin.

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Copyright 2014 Washington University School of Medicine