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Psychiatry

Li-Shiun Chen, MD, MPH, ScD

Current Position
Instructor, Psychiatry

Specialty Areas
Schizophrenia
Mood Disorders
Psychiatry

Patients Seen At
4444 Forest Park Ave., Suite 2100
St. Louis, MO  63108
(314) 286-1700
Fax:   (314) 286-1777
View Driving Directions

Mailing Address
Department of Psychiatry
Washington University School of Medicine
660 So. Euclid Avenue, Campus Box 8134
St. Louis, MO  63110

Areas of Clinical Interest
Schizophrenia, early psychosis, mood disorders, substance dependence, community psychiatry, genetics, family and sibling studies.



Dr. Chen is the adolescent & adult psychiatry assessment supervisor for the First Contact Assessment Service, which evaluates individuals who are showing early signs of a possible psychotic disorder such as schizophrenia. In addition to assessment by a psychiatrist, First Contact assessments include diagnostic interviews and cognitive testing by a psychologist. The First Contact Assessment Service generally does not follow patients over time, but provides evaluation reports to the treating psychiatrist.

Board Certification
Certified -- Psychiatry

Medical Education
Medical Degree: National Taiwan University, School of Medicine, Taipei, Taiwan, 1993
M.P.H.: Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland, 1995
Sc.D.: Psychiatric Epidemiology, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland, 1998
Hospital Affiliations
Barnes-Jewish Hospital

Honors and Awards
Employee of the Month, BJC Behavioral Health, 2005
Eli Robins Award, Washington University Department of Psychiatry, 2004
APA Resident Research Award, 2004
APA/Lilly Executive Leadership Conference, sponsored participant, 2004

Selected or Recent Journal Articles
Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S. CHRNA5 Variant Predicts Smoking Cessation in Patients With Acute Myocardial Infarction. Nicotine Tob Res. 2014 Apr 11. [Epub ahead of print]

Bloom AJ, Baker TB, Chen LS, Breslau N, Hatsukami D, Bierut LJ, Goate A. Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. Hum Mol Genet. 2014 Jan 15;23(2):555-61.

Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L. Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction. 2014 Jan;109(1):128-37.

Bloom AJ, Martinez M, Chen LS, Bierut LJ, Murphy SE, Goate A. CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes. PLoS One. 2013 Nov 15;8(11):e79700.

Chen LS, Baker TB, Piper ME, Breslau N, Cannon DS, Doheny KF, Gogarten SM, Johnson EO, Saccone NL, Wang JC, Weiss RB, Goate AM, Bierut LJ. Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. Am J Psychiatry. 2012 Jul 1;169(7):735-42.

Chen LS, Xian H, Grucza RA, Saccone NL, Wang JC, Johnson EO, Breslau N, Hatsukami D, Bierut LJ. Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes. Drug Alcohol Depend. 2012 Jun;123 Suppl 1:S42-51.

Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, Wenzlaff AS, Wu C, Yoon D, Chen YT, Cheng YC, Cho YS, David SP, Duan J, Eaton CB, Furberg H, Goate AM, Gu D, Hansen HM, Hartz S, Hu Z, Kim YJ, Kittner SJ, Levinson DF, Mosley TH, Payne TJ, Rao DC, Rice JP, Rice TK, Schwantes-An TH, Shete SS, Shi J, Spitz MR, Sun YV, Tsai FJ, Wang JC, Wrensch MR, Xian H, Gejman PV, He J, Hunt SC, Kardia SL, Li MD, Lin D, Mitchell BD, Park T, Schwartz AG, Shen H, Wiencke JK, Wu JY, Yokota J, Amos CI, Bierut LJ. Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol. 2012 May;36(4):340-51.

Chen LS, Baker TB, Grucza R, Wang JC, Johnson EO, Breslau N, Hatsukami D, Smith SS, Saccone N, Saccone S, Rice JP, Goate AM, Bierut LJ. Dissection of the phenotypic and genotypic associations with nicotinic dependence. Nicotine Tob Res. 2012 Apr;14(4):425-33.

Chen LS, Johnson EO, Breslau N, Hatsukami D, Saccone NL, Grucza RA, Wang JC, Hinrichs AL, Fox L, Goate AM, Rice JP, Bierut LJ. Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence. Addiction. 2009 Oct;104(10):1731-1740.

Grucza RA, Johnson EO, Krueger RF, Breslau N, Saccone NL, Chen LS, Derringer J, Agrawal A, Lynskey M, Bierut LJ. Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. Addict Biol. 2010 Jul;15(3):346-57.

Chen LS, Rice TK, Thompson PA, Barch DM, Csernansky JG. Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia. Schizophr Res. 2009 Jun;111(1-3):159-66.

Chen LS, Emmert-Streib F, Storey JD. Harnessing naturally randomized transcription to infer regulatory relationships among genes. Genome Biol. 2007;8(10):R219.

Freedman DM, Cantor KP, Lee NL, Chen LS, Lei HH, Ruhl CE, Wang SS. Bladder cancer and drinking water: a population-based case-control study in Washington County, Maryland (United States). Cancer Causes Control. 1997 Sep;8(5):738-44.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Li-Shiun Chen.


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Copyright 2014 Washington University School of Medicine