Obstetrics and Gynecology / Gynecologic Oncology

The physicians of the Division of Gynecologic Oncology care for women who present with the diagnosis of a possible gynecologic cancer or a pre-cancerous condition.

This includes women who have had abnormal pap smears and/or cervical lesions and need additional work-up to rule out the possibility of cervical cancer; patients with abnormal uterine bleeding to rule out endometrial cancer; patients with vulvar irritations and/or lesions to rule out vulvar cancer; and patients with adnexal or pelvic masses to rule out ovarian cancer.

Patients may be self-referred or may be referred to the division by other physicians from the metropolitan St. Louis area, as well as beyond. It is not uncommon for patients to travel hundreds of miles to be cared for by one of the gynecologic oncology specialists at Washington University.

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Israel Zighelboim, MD

Specialty Areas
Gynecologic Oncology
Ovarian Cancer
Cervical Cancer
Endometrial Cancer

Additional Languages Spoken
Spanish

Areas of Clinical Interest
Minimally-invasive gynecologic surgery, management of women at genetically increased risk for gynecologic cancers, gynecologic oncology, endometrial cancer, vulva carcinoma, ovarian cancer, cervical cancer, adnexal masses, tumors, hysterectomy, lymphadenectomy, endometrial adenocarcinomas, cervical intraepithelial neoplasia, gynecologic malignancies, ob/gyn, women's health.

Areas of Research Interest
Genetics of endometrial cancer and treatment outcomes in gynecologic malignancies.

Major or Recent Publications/Awards

Honors and Awards
President’s Award. The St. Louis Gynecological Society Annual Scientific Meeting: ATR Mutation in Uterine Cancer is Associated with Poor Disease Free and Overall Survival. St. Louis, MO. April, 2007
Best Fourth Year Resident. Academic Year 2004-2005. Baylor College of Medicine. Department of Obstetrics and Gynecology. Houston, TX. June 25, 2005.
Award / Resident Mentor of the Year. Academic Year 2004-2005. Baylor College of Medicine. Department of Obstetrics and Gynecology. Houston, TX. June, 2005.
Teaching Excellence Award. Baylor College of Medicine. Houston, TX. Academic year, 2004-2005.

Editorial Responsibilities
Reviewer Ad Hoc
Cancer Epidemiology Biomarkers & Prevention
Cancer Research
Clinical Cancer Research
Current Medicinal Chemistry
Gynecologic Oncology
Experimental and Molecular Pathology

Peer Reviewed Publications

Nugent EK, Zighelboim I, Case AS, Gao F, Thaker PH, Rader JS, Mutch DG, Massad LS. The value of perioperative imaging in patients with uterine sarcomas. Gynecol Oncol 2009; In Press.

Zighelboim I, Schmidt AP, Gao F, Thaker PH, Powell MA, Rader JS, Gibb RK, Mutch DG, Goodfellow PJ. ATR Mutation in Endometrioid Endometrial Cancer is Associated with Poor Clinical Outcomes. J Clin Oncol 2009; In Press.

Kizer NT, Zighelboim I, Case AS, Dewdney SB, Thaker PH, Massad LS. The Role of PET/CT in the Management of Cervical Cancer Patients: Practice Patterns of Members of the Society of Gynecologic Oncologists. Gynecol Oncol 2009; In Press.

Hagemann AR, Zighelboim I, Odibo AO, Gibb RK, Rader JS, Mutch DG, Powell MA. Cost-benefit of laparoscopic versus medical ovarian suppression in premenopausal breast cancer. Breast J 2009; In Press.

Kizer N, Zighelboim I, Rader J. Cardiac Arrest during Argon Beam Coagulation of Metastatic Ovarian Cancer. Int J Gynecol Cancer 2009; 19: 237-238.

Zighelboim I, Goodfellow PJ. Response to Buda et al [Letter]. Gynecol Oncol 2008; 110: 266.

Rader JS, Malone JP, Gross J, Gilmore P, Brooks RA, Nguyen L, Crimmins DL, Feng S, Wright JD, Taylor N, Zighelboim I, Funk MC, Huettner PC, Ladenson JH, Gius D, Townsend RR. A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening. Proteomics Clin Appl 2008; 2: 1658-1669.

Tung CS, Zighelboim I, Gardner MO. Acute colonic pseudoobstruction complicating twin pregnancy. J Reprod Med 2008; 53: 52-4.

Zighelboim I, Goodfellow PJ. RE: Spurdle and Webb [Letter]. Gynecol Oncol 2008; 109: 154.

Case AS, Zighelboim I, Mutch DG, Bab SA, Schmidt AP, Whelan AJ, Thibodeau SN, Goodfellow PJ. Clustering of Lynch syndrome malignancies with no evidence of a role of DNA mismatch repair. Gynecol Oncol 2008;108: 438-44.

Thaker P, Kizer NT, Nguyen T, Zighelboim I, Allsworth J. Discussion: 'Value of HPV testing in follow-up of treated high-risk CIN1' by Alonso et al. Am J Obstet Gynecol 2007;197: 433-4; discussion e1-4.

Zighelboim I, Goodfellow PJ, Gao F, Gibb RK, Powell MA, Rader JS, Mutch DG. The impact of microsatellite instability and epigenetic inactivation of MLH1 on the outcome of patients with endometrial carcinomas of the endometrioid type. J Clin Oncol 2007; 25: 2042-8.

Zighelboim I, Goodfellow PJ, Schmidt AP, Walls KC, Mallon MA, Mutch DG, Yan PS, Huang TH, Powell MA. Differential methylation hybridization array of endometrial cancers reveals two novel cancer specific methylation markers. Clin Cancer Res 2007; 13: 2882-9.

Zighelboim I, Babb S, Gao F, Powell MA, Mutch DG, Goodfellow PJ. Excess of early onset multiple myeloma in endometrial cancer probands and their relatives suggests common susceptibility. Gynecol Oncol 2007; 105: 390-4.

Goetzl L, Rivers J, Zighelboim I, Wali A, Badell M, Suresh MS. Intrapartum epidural analgesia and maternal temperature regulation. Obstet Gynecol 2007; 109: 687-90.

Zighelboim I, Ramirez PT, Gao F, Slomovitz BM, Sun C, Frumovitz M, Jhingran A, Levenback C. Retroperitoneal lymph node resection in patients with cervical cancer. Surg Oncol 2006; 15: 79-83.

 Zighelboim I, Taylor NP, Powell MA, Gibb RK, Rader JS, Mutch DG, Grigsby P. Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapy. Radiat Med 2006; 24: 625-30.

Taylor NP, Zighelboim I, Huettner PC, Powell MA, Gibb RK, Rader JS, Mutch DG, Edmonston TB, Goodfellow PJ. DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis. Mod Pathol 2006; 19: 1333-1338.

Goetzl L, Zighelboim I, Badell M, Rivers J, Mastrangelo MA, Tweardy D, Suresh MS. Maternal Corticosteroids to Prevent Intrauterine Exposure to Hyperthermia and Inflammation; A Randomized, Double-Blind, Placebo-Controlled Trial. Am J Obstet Gynecol 2006;195:1031-1037.

Tung CS, Zighelboim I, Scott BG, Anderson ML. Human acellular dermal matrix for closure of a contaminated gynecologic wound. Gynecol Oncol 2006; 103: 354-356.

Zighelboim I, Broaddus R, Ramirez PT. Atypical sigmoid metastasis from a high-grade mixed adenocarcinoma of the ovary. Gynecol Oncol 2004; 94: 850-853.

Zighelboim I, Henao G, Kunda A, Gutierrez C, Edwards C. Gastrointestinal stromal tumor presenting as a pelvic mass. Gynecol Oncol 2003; 91: 630-635.

Tita ATN, Zighelboim I. Do women prefer female obstetricians? (Letter). Obstet Gynecol 2002; 100:827-828.

Zighelboim I, Zighelboim I. Prevención del síndrome de la abuela. Estudio preliminar. Rev Obstet Ginecol Venez 2002; 62(1): 17-20.

Zighelboim I, Medrano R, Varnagy D. Manejo en el hogar de cuadros diarréicos agudos del lactante y uso de la terapia de rehidratación oral en la comunidad rural de Cumbo – Estado Miranda. Gac Med Caracas 2001; 109(1): 48-54.

Benítez G, Nakhal E, Zighelboim I, Godayol F, Pozo JC. Enfermedad de Gaucher: presentación de un caso. Rev Venez Cir 2000; 53:42-45.

Torres RD, Zighelboim R I, Varnagy G D, Velasquez PC, Velasquez PO. Prevalencia de ascariasis en pacientes pediátricos del medio nosocomial público y privado. Gac Med Caracas 1999; 107:212-218.

Zighelboim I, Magnelli A, Zighelboim R I. Parto inducido y espontáneo: Su duración y frecuencia horaria [Induced and spontaneous labor: its duration and hourly frequency]. Ginecol Obstet Méx 1997; 65:470-473.

Invited Review Articles, Book Chapters and Other Publications

Zighelboim I. 2009. Gene mutation marks aggressive endometrial cancer. News release [online]. [Accessed 05.22.2009]:
http://mednews.wustl.edu/news/page/normal/14216.html?emailID=24334

Zighelboim I. 2009. Siteman, Barnes-Jewish Advancing Use of da Vinci Robot in Operating Room. Video [online]. [Accessed 05.22.2009]: http://news.barnesjewish.org/pr/bjh/electronicplay.aspx?fid=69988&id=E0C8328

Zighelboim I. 2009. Doctors Say Genetic Evaluation Important for People with Family History of Cancer. News release [online]. [Accessed 05.22.2009]: http://news.barnesjewish.org/pr/bjh/genetic-evaluation-important-for-people-with-family-history-of-cancer.aspx

Zighelboim I. 2009. Genetics and Gynecologic cancer. Podcast [online]. [Accessed 04.07.2009]: http://news.barnesjewish.org/pr/bjh/podcast-post.aspx?id=1554. Genetic Risk Factors for Ovarian and Endometrial Cancer. Podcast [online]. [Accessed 04.20.2009]: http://www.siteman.wustl.edu/internal.aspx?id=1472

Hagemann AR, Zighelboim I. Gynecologic Oncology. In: Cashen AF, Wildes TM (Editors). Hematology and Oncology Subspecialty Consult. 2nd Edition. Philadelphia: Wolters Kluwer / Lippincott Williams & Wilkins; 2008. p. 287-98.

Zighelboim I, Powell MA. Uterine Corpus Cancer. In: Gynecologic Oncology. Gehrig P and Alvarez Secord A (editors). Landes Bioscience. USA. 2006.

Zighelboim I, Geevarghese S, Mutch DG. HPV Vaccines: The second hit to cervical cancer. Postgraduate Obstetrics and Gynecology 2006; 26(12): 1-6.

Sosa L, Negrin M, Gil C, Zighelboim R I. La piel y sus anexos. Department of Normal Histology and Embriology. Escuela de Medicina Luis Razetti, Facultad de Medicina, Universidad Central de Venezuela. Caracas, March 1998.

Israel Zighelboim, MD