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Otolaryngology / Pediatric

Keiko Hirose, MD

Current Position
Associate Professor, Otolaryngology - Head and Neck Surgery
Division Director, Pediatric Otolaryngology


Specialty Areas
Pediatric Otolaryngology
Hearing Loss
Cochlear Implants - Pediatric
Ear, Nose and Throat
Cleft Lip and Palate
Craniofacial Reconstructive Surgery

Additional Features & Interview with Dr. Hirose:

Top Story Interview: Dr. Hirose discusses cochlear implants.

Patients Seen At
St. Louis Children's Hospital
One Children's Place, Third Floor
St. Louis, MO  63110
314-454-6162
Fax:   314-454-2174
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Otolaryngology
660 South Euclid Avenue, Campus Box 8115
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric hearing loss, cochlear implantation, chronic ear surgery, cholesteatoma, conductive hearing loss, aural atresia, BAHA, ear infections, speech disorders, velopharyngeal insufficiency, cleft palate, craniofacial disorders

Areas of Research Interest
Cochlear inflammation and mononuclear phagocytes in repair of the damaged cochlea.

Board Certification
Otolaryngology -- Certified

Medical Education
B.A.: Columbia College, Columbia University, New York, 1989
Medical Degree: Harvard Medical School, Boston, Massachusetts, 1993
Residency: Otolaryngology, University of Washington Medical Center, Seattle, Washington, 1999
Fellowship: Pediatric Otolaryngology, Children's Hospital of Boston, Boston, Massachusetts, 2000
Hospital Affiliations
Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
St. Louis Children's Hospital

Honors and Awards
Listed in Best Doctors in America, Inc., 2006-2013 (Best Doctors, Inc.)
Cleveland Top Doctors, 2006, 2007

Selected or Recent Journal Articles
Warchol ME, Schwendener RA, Hirose K. Depletion of resident macrophages does not alter sensory regeneration in the avian cochlea. PLoS One. 2012.

Hirose K, Sato E. Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea. Hear Res. 2011 Feb.

Jeyakumar A, Brickman TM, Williamson ME, Hirose K, Krakovitz P, Whittemore K, Discolo C. Nonsteroidal anti-inflammatory drugs and postoperative bleeding following adenotonsillectomy in pediatric patients. Arch Otolaryngol Head Neck Surg. 2008 Jan.

Sato E, Shick HE, Ransohoff RM, Hirose K*. The role of CX3CR1 in aminoglycoside ototoxicity. Submitted to Journal of Neuroscience.

Gao J, Maison SF, Wu X, Hirose K, Jones, SM, Bayazitov I, Tian Y, Mittleman G, Matthews D, Zakharenko S, Liberman MC, Zuo J. The orphan glutamate receptor delta1 subunit is required for high-frequency hearing, Molecular and Cellular Biology. 2007;27(12):4500-4512.

Sato E, Shick HE, Ranshoff RM, Hirose K*. Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1. In press, Journal of Comparative Neuology, 2007.

Cannady S, Hirose K, Koltai PJ. Surgical Management of Cervical Ganglioneuromas in Children. International Journal of Pediatric Otorhinolaryngology, 2006;70(2):287-94.

Rowe T, Rizzi M, Hirose K, Peters G, Sen GC. Novel role of the double stranded RNA-binding protein, PACT in mouse ear development and hearing. Proceedings of the National Academy of Sciences, 2006:103(15):5823-8.

Sautter NB, Shick HE, Ransohoff RM, Charo IF, Hirose K*. CC chemokine receptor 2 (CCR2) is protective against noise-induced hair cell death. Journal of the Association for Research in Otolaryngology. 2006: 7(4):361-72.

Hildebrand MS, de Silva MG, Klockars T, Solares CA, Hirose K, Smith JD, Patel, SC, Dahl HHM. Expression of the carrier protein apolipoprotein D in the mouse inner ear. Hearing Research, 2005;200:102-114.

Hirose K*, Discolo C, Keasler J, Ransohoff R. Mononuclear Phagocytes Migrate into theMurine Cochlea after Acoustic Trauma. Journal of Comparative Neurology, 2005;489:180-194.

Hirose K, Westrum LE, Cunningham DE, Rubel EW. Electron microscopy of degenerative changes in the chick basilar papilla after gentamicin exposure. J Comp Neurol. 2004 Mar 1.

Solares CA, Edling AE, Hirose K, Hughes GB, Tuohy VK. Experimental autoimmune hearing loss mediated by CD4+ T cells specific for mouse inner ear peptides. Journal of Clinical Investigation. 2004;113:1210-1227.

Solares CA, Krakovitz P, Hirose K, Koltai PJ. Starplasty: revisiting a pediatric tracheostomy technique. Otolaryngol Head Neck Surg. 2004;131(5):717-22.

Hirose K* and Liberman MC. Lateral wall histopathology and endocochlear potential in the noise damaged mouse cochlea. Journal of the Association for Research in Otolaryngology. 2003;04:339-352.

Discolo C and Hirose K*. Pediatric Cochlear Implants. American Journal of Audiology, 2003;11:114-118.

Hirose K, Wener MH, Duckert LG. Utility of laboratory testing in autoimmune inner ear disease. Laryngoscope. 1999 Nov.

Hirose K, Westrum LE, Stone JS, Zirpel L, Rubel EW. Dynamic studies of ototoxicity in mature avian auditory epithelium. Ann N Y Acad Sci. 1999 Nov 28.

Hirose K, Hockenbery DM, Rubel EW. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res. 1997 Feb.


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Copyright 2014 Washington University School of Medicine