Evan D. Kharasch, MD, PhD
Current Position
Professor, Anesthesiology
Specialty Areas
Clinical Pharmacology
Mailing Address
|
Washington University School of Medicine
Department of Anesthesiology
660 South Euclid Avenue
Campus Box 8054
St. Louis,
MO
63110
|
Areas of Research Interest
Clinical Pharmacology
Drug Metabolism
Drug Interactions
Cytochrome P450
Mechanisms of Anesthetic Toxicity
Interindividual and Pharmacogenetic Variability in Drug Disposition and Drug Effects
Haloalkane and Haloalkene Toxicology
Board Certification
Anesthesiology
--
Certified
Advanced Cardiac Life Support
--
Certified
Medical Education
B.S.: Medical Science, Northwestern University, Evanston, Illinois
, 1977
M.D.: Northwestern University Medical School, Evanston, Illinois
, 1979
Ph.D.: Pharmacology, Northwestern University, Chicago, Illinois
, 1983
Residency: Anesthesiology, University of Washington Hospitals, Seattle, Washington
, 1988
Hospital Affiliations
Barnes-Jewish Hospital, St. Louis, Missouri
Major or Recent Publications/Awards
Honors and Awards
Inaugural Member, Honorary Academy of Mentors, American Society of Anesthesiologists Foundation for Anesthesia Education and Research, 2004
Faculty Development Award in Clinical Pharmacology, Pharmaceutical Manufacturers Association Foundation, 1993
Young Investigator Award, Foundation for Anesthesia Education and Research, 1990
B.B. Sankey Anesthesia Advancement Award, International Anesthesia Research Society, 1989
Select Publications
Coles R, Kharasch ED. Stereoselective analysis of bupropion and hydroxybupropion in human plasma and urine by LC/MS/MS. J Chrom, 2007; 857:67-75
Kharasch ED, Walker A, Isoherranen N, Hoffer C, Sheffels P, Thummel K, Whittington D, Ensign D. Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. Clin Pharmacol Ther, 2007; 82:410-26
Kharasch ED. Every breath you take, we'll be watching you. Anesthesiology, 2007; 106:652-54
Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED. Enantiomeric metabolic interactions and stereoselective human methadone metabolism. J Pharmacol Exp Ther, 2007; 321:389-399
Kirby B, Kharasch ED, Thummel KT, Narang VS, Hoffer CJ, Unadkat JD. Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. J Clin Pharmacol, 2006; 46:1313-9