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Neurology / Adult

Robert H. Baloh, MD, PhD

Current Position
Assistant Professor, Neurology
Division of Adult Neurology


Specialty Areas
Neurology - Adult
Muscle Disorders
Peripheral Neuropathy
ALS - Lou Gehrig's Disease

Patients Seen At
Neuroscience Center
Center for Advanced Medicine
4921 Parkview Place, Suite C, 6 Fl
St. Louis, MO  63110
314-362-6981
Fax:   314-362-3752
View Floor Map  View Campus Map   View Driving Directions

Mailing Address
Department of Neurology
Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8111
St. Louis, MO  63110

Areas of Clinical Interest
Muscle weakness, numbness and sensory loss, cramps and muscle pain, peripheral neuropathy, motor neuron disease (ALS), inflammatory diseases of muscle and nerve (i.e. dermatomyositis, CIDP), muscular dystrophy, Charcot-Marie-Tooth disease, myasthenia gravis

Board Certification
Neurology -- Certified

Medical Education
B.S.: Neuroscience, Brown University, Providence, Rhode Island, 1995
Chief Residency: Neurology, Partners Neurology (Massachusetts General Hospital/Brigham and Women's Hospital) Boston, Massachusetts, 1995
Ph.D.: Washington University School of Medicine, St. Louis, Missouri, 2001
Medical Degree: Washington University School of Medicine, St. Louis, Missouri , 2001
Residency : Neurology, Partners Neurology (Massachusetts General Hospital / Brigham and Women’s Hospital), Boston, Massachusetts, 2004
Fellowship: Neuromuscular Disease, Washington University School of Medicine, St. Louis, Missouri, 2006
Hospital Affiliations
Barnes-Jewish Hospital

Honors and Awards
S. Weir Mitchell Award, American Academy of Neurology, 2007

Elsevier Prize for best presentation entitled “In vitro mechanisms of Charcot-Marie-Tooth associated mitofusin 2 mutations,” World Muscle Society, 2006

Selected or Recent Journal Articles
Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci. 2014 Mar 30.

Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. TREM2 Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis. JAMA Neurol. 2014 Feb 17.

Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH. Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. Hum Mol Genet. 2014 Jan 1;23(1):157-70.

Harms MB, Baloh RH. Clinical neurogenetics: amyotrophic lateral sclerosis. Neurol Clin. 2013 Nov;31(4):929-50.

Harms MB, Cady J, Zaidman C, Cooper P, Bali T, Allred P, Cruchaga C, Baughn M, Libby RT, Pestronk A, Goate A, Ravits J, Baloh RH. Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis. Neurobiol Aging. 2013 Sep;34(9):2234.e13-9.

Harms MB, Ori-McKenney KM, Scoto M, Tuck EP, Bell S, Ma D, Masi S, Allred P, Al-Lozi M, Reilly MM, Miller LJ, Jani-Acsadi A, Pestronk A, Shy ME, Muntoni F, Vallee RB, Baloh RH. Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy. Neurology. 2012 May 29;78(22):1714-20.

Misko AL, Sasaki Y, Tuck E, Milbrandt J, Baloh RH. Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration. J Neurosci. 2012 Mar 21;32(12):4145-55.

Harms MB, Sommerville RB, Allred P, Bell S, Ma D, Cooper P, Lopate G, Pestronk A, Weihl CC, Baloh RH. Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy. Ann Neurol. 2012 Mar;71(3):407-16.

Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E952-61.

Baloh RH. TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. FEBS J. 2011 Oct;278(19):3539-49.

Sommerville RB, Baloh RH. Anemia, paresthesias, and gait ataxia in a 57-year-old denture wearer. Clin Chem. 2011 Aug;57(8):1103-6.

Viader A, Golden JP, Baloh RH, Schmidt RE, Hunter DA, Milbrandt J. Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci. 2011 Jul 13;31(28):10128-40.

Weihl CC, Miller SE, Zaidman CM, Pestronk A, Baloh RH, Al-Lozi M. Novel GNE mutations in two phenotypically distinct HIBM2 patients. Neuromuscul Disord. 2011 Feb;21(2):102-5.

Udan M, Baloh RH. Implications of the prion-related Q/N domains in TDP-43 and FUS. Prion. 2011 Jan-Mar;5(1):1-5. Epub 2011 Jan 1. Review.

Wegorzewska I, Baloh RH. TDP-43-based animal models of neurodegeneration: new insights into ALS pathology and pathophysiology. Neurodegener Dis. 2011;8(4):262-74.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Robert H. Baloh.


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