Internal Medicine / Infectious Diseases

The Washington University physicians in the Department of Internal Medicine encompass 14 specialty clinical divisions.

Over 270 physicians in the department of medicine treat patients with a wide range of diseases, disorders and conditions.

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Jeffrey Parker Henderson, MD, PhD

Specialty Areas
Infectious Diseases

Areas of Clinical Interest
Infectious diseases

Areas of Research Interest
Pathophysiology of enteric gram negative infections


Major or Recent Publications/Awards

Honors and Awards

Washington University Internal Medicine Club Research Award, 2002

The Walter Nicolai Award for Meritorious Research In Biomedical Gerontology, First Place, American
Federation for Aging Research Grantee Conference "Halogenation of DNA by the Myeloperoxidase System of Activated Phagocytes: Implications for Carcinogenesis at Sites of Inflammation", 2001

Books and Book Chapters

Henderson JP, Heinecke JW.
“Myeloperoxidase and Eosinophil Peroxidase: Phagocyte Enzymes for Halogenation in Humans”, The Handbook of Environmental Chemistry: The Natural Production of Halogenated Compounds. 2003; Vol. 3, pp 201-214

Selected Publications

Yeh GC, Henderson JP, Byun J, d'Avignon D, Heinecke JW. 8-Nitroxanthine, a Product of Myeloperoxidase, Peroxynitrite, and Activated Human Neutrophils, Enhances Generation of Superoxide by Xanthine Oxidase. Archives of Biochemistry and Biophysics 2003; 418(1):1-12

Byun J, Henderson JP, Heinecke JW. Identification and Quantification of Mutagenic Halogenated Cytosines by Gas Chromatography, Fast Atom Bombardment, and Electrospray Ionization Tandem Mass Spectrometry. Analytical Biochemistry 2003; 317(2): 201-209

Henderson JP, Byun J, Takeshita J, Heinecke JW. Phagocytes Produce 5-Chlorouracil and 5-Bromouracil, Two Mutagenic Products of Myeloperoxidase in Human Inflammatory Tissue. Journal of Biological Chemistry 2003; 278(26):23522-23528

Gaut JP, Yeh GC, Tran HD, Byun J, Henderson JP, Richter GM, Belaaouaj A, Hotchkiss RS and Heinecke JW. Neutrophils generate antimicrobial brominating and chlorinating oxidants during sepsis, Proceedings of the National Academy of Sciences, USA 2001; 98(21):11961-11966

Henderson JP, Byun J, Williams MV, McCormick ML, Parks WC, Ridnour LA, Heinecke JW. Bromination of deoxycytidine by eosinophil peroxidase: A Mechanism for Mutagenesis by Oxidative Damage of Nucleotide Precursors, Proceedings of the National Academy of Sciences, USA 2001; 98(4):1631-1636

Henderson JP, Byun J, Williams MV, Mueller DM, McCormick ML, Heinecke JW. Production of brominating intermediates by myeloperoxidase: A Transhalogenation Pathway for Generating Mutagenic Nucleobases during Inflammation, Journal of Biological Chemistry 2001; 276(11):7867-7875

Henderson JP, Byun J, Mueller DM, Heinecke JW. The Eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-Bromouracil, a Mutagenic Thymine Analog, Biochemistry 40(7):2052-2059, 2001.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Jeffrey Henderson

Jeffrey Parker Henderson, MD, PhD