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Neurology / Adult

Randall J. Bateman, MD

Current Position
Charles F. and Joanne Knight Distinguished Professor, Neurology
Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)


Specialty Areas
Memory Disorders and Diagnosis
Dementia
Alzheimer's Disease
Neurology - Adult

Patients Seen At
Memory Diagnostic Center
Center for Advanced Medicine
4921 Parkview Place, Suite C, 6th Floor
St. Louis, MO  63110
(314) 286-1967
Fax:   (314) 286-1985
View Floor Map  View Campus Map   View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Neurology
660 South Euclid, Campus Box 8111
St. Louis, MO  63110

Areas of Clinical Interest
Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

Board Certification
Neurology -- Certified

Medical Education
B.S.: Electrical Engineering, Washington University, St. Louis, Missouri, 1996
B.S.: Biology, Washington University, St. Louis, Missouri, 1996
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, Ohio, 2000
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri, 2004
Clinical Fellowship: Dementia, Washington University School of Medicine, St. Louis, Missouri, 2005
Hospital Affiliations
Barnes-Jewish Hospital

Editorial Responsibilities

Editorial Board
Alzheimer’s Research & Therapy

Ad hoc Reviewer
New England Journal of Medicine
Analytical Chemistry
Annals of Neurology
Brain
Science
Journal of Neuroscience
Neuroscience Letters
Neurobiology of Aging
Archives of Neurology
Alzheimer’s Disease and Associated Disorders
Neurology

Honors and Awards
Chancellor’s Award for Innovation and Entrepreneurship, Washington University, 2013

MetLife Promising Investigator Award, 2012

American Society for Clinical Investigation Council, 2012

Alzheimer’s Association Zenith Fellows Award, 2011

Alzheimer Research Forum Open Innovation Award, 2011

American Neurological Associate Membership, 2011

Glenn Award for Research in Biological Mechanisms of Aging, 2011

Co-Recipient, Health Care Heroes in Innovation by the St. Louis Business Journal, 2010

St. Louis Academy of Science Innovator of the Year Award, 2009

Kopolow Award, 2007

World Technology Award Nominee for Health and Medicine Associate, 2006

Scientific American 50, award for outstanding technological leadership, one of the top 50 scientific advancements, 2006

American Neurological Association Plenary Session Speaker, 2005

AAN Platform Presentation and Travel Fellowship Award, 2005

AAN Foundation Corporate Roundtable Clinical Research Training Fellowship, 2004

Undergraduate Research Fellowship, Howard Hughes Medical Institute, 1994

Selected or Recent Journal Articles
Dobrowolska JA, Kasten T, Huang Y, Benzinger TL, Sigurdson W, Ovod V, Morris JC, Bateman RJ. Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system. PLoS One. 2014 Mar 19;9(3):e89998.

Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM; Dominantly Inherited Alzheimer Network. Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer's Disease. Sci Transl Med. 2014 Mar 5;6(226):226ra30.

Benzinger TL, Blazey T, Jack CR Jr, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, Christensen JJ, Ercole L, Hornbeck RC, Farrar AM, Aldea P, Jasielec MS, Owen CJ, Xie X, Mayeux R, Brickman A, McDade E, Klunk W, Mathis CA, Ringman J, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Salloway S, Correia S, Schofield PR, Masters CL, Rowe C, Villemagne VL, Martins R, Ourselin S, Rossor MN, Fox NC, Cash DM, Weiner MW, Holtzman DM, Buckles VD, Moulder K, Morris JC. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4502-9.

Moulder KL, Snider BJ, Mills SL, Buckles VD, Santacruz AM, Bateman RJ, Morris JC. Dominantly Inherited Alzheimer Network: facilitating research and clinical trials. Alzheimers Res Ther. 2013 Oct 17;5(5):48. [Epub ahead of print]

Cash DM, Ridgway GR, Liang Y, Ryan NS, Kinnunen KM, Yeatman T, Malone IB, Benzinger TL, Jack CR Jr, Thompson PM, Ghetti BF, Saykin AJ, Masters CL, Ringman JM, Salloway SP, Schofield PR, Sperling RA, Cairns NJ, Marcus DS, Xiong C, Bateman RJ, Morris JC, Rossor MN, Ourselin S, Fox NC; Dominantly Inherited Alzheimer Network (DIAN). The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study. Neurology. 2013 Oct 15;81(16):1425-33.

Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, Farlow M, Fox N, Ghetti B, Goate AM, Heinrichs D, Hornbeck R, Jack C, Jucker M, Klunk WE, Marcus DS, Martins RN, Masters CM, Mayeux R, McDade E, Morris JC, Oliver A, Ringman JM, Rossor MN, Salloway S, Schofield PR, Snider J, Snyder P, Sperling RA, Stewart C, Thomas RG, Xiong C, Bateman RJ. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev Neurol (Paris). 2013 Oct;169(10):737-43.

Mawuenyega KG, Kasten T, Sigurdson W, Bateman RJ. Amyloid-beta isoform metabolism quantitation by stable isotope-labeled kinetics. Anal Biochem. 2013 Sep 1;440(1):56-62.

Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, Mawuenyega K, Blazey T, Goate A, Chott R, Yarasheski KE, Holtzman DM, Morris JC, Benzinger TL, Bateman RJ. Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Sci Transl Med. 2013 Jun 12;5(189):189ra77.

Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL. Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls. Ann Neurol. 2013 Jan;73(1):104-19.

Huang Y, Potter R, Sigurdson W, Kasten T, Connors R, Morris JC, Benzinger T, Mintun M, Ashwood T, Ferm M, Budd SL, Bateman RJ. β-Amyloid Dynamics in Human Plasma. Arch Neurol. 2012 Dec;69(12):1591-7.

Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, Oliver A, Quaid K, Ringman JM, Rossor MN, Salloway S, Schofield PR, Selsor NJ, Sperling RA, Weiner MW, Xiong C, Moulder KL, Buckles VD. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clin Investig (Lond). 2012 Oct 1;2(10):975-984.

Roh JH, Huang Y, Bero AW, Kasten T, Stewart FR, Bateman RJ, Holtzman DM. Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology. Sci Transl Med. 2012 Sep 5;4(150):150ra122.

Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC; Dominantly Inherited Alzheimer Network. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med. 2012 Aug 30;367(9):795-804.

Bateman RJ, Boychuk CR, Philbin KE, Mendelowitz D. β adrenergic receptor modulation of neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Neuroscience. 2012 May 17;210:58-66.

Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, Yarasheski KE, Wang JX, Mawuenyega KG, Jiang H, Parsadanian M, Yoon H, Kasten T, Sigurdson WC, Xiong C, Goate A, Holtzman DM, Bateman RJ. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. PLoS One. 2012;7(6):e38013.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Randall J. Bateman.

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Copyright 2014 Washington University School of Medicine