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Pediatrics

Patrick Y. Jay, MD, PhD

Current Position
Associate Professor, Pediatrics
Division of Pediatric Cardiology


Specialty Areas
Pediatric Cardiology

Patients Seen At
St. Louis Children's Hospital
One Children's Place, Second Floor, Suite D
St. Louis, MO  63110
314-454-6095
Fax:   314-454-2561
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Pediatrics
Campus Box 8116, 660 S. Euclid Ave
St. Louis, MO  63110

Academic Office
St. Louis Children's Hospital
One Children's Place, 5S30
St. Louis, MO  63110
(314) 362-2174

Areas of Clinical Interest
Heart disease in children, congenital heart condition, pediatric cardiology, 2nd opinion,

Board Certification
Pediatrics -- Certified
Pediatric Cardiology -- Certified

Medical Education
Ph.D.: Washington University School of Medicine, St. Louis, MO, 1995
Medical Degree: Washington University School of Medicine, St. Louis, MO, 1995
Residency: Children's Hospital, Boston, MA, 1997
Fellowship: Pediatric Cardiology, Children's Hospital, Boston, MA, 2001
Fellowship: Post Doctorate Research, Beth Israel Deaconness Medical Ctr, Harvard Medical School, Boston, MA, 2004
Hospital Affiliations
St. Louis Children's Hospital

Honors and Awards 
Richard D. Rowe Award in Perinatal Cardiology, 2004
Chancellor's Hartwell Prize for Innovative Research, Washington University, 2005

Selected or Recent Journal Articles
Chen IB, Rathi VK, DeAndrade DS, Jay PY. Association of genes with physiological functions by comparative analysis of pooled expression microarray data. Physiol Genomics. 2013 Jan 15;45(2):69-78.

Vyas AK, Aerni-Flessner LB, Payne MA, Kovacs A, Jay PY, Hruz PW. Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy. Cardiovasc Endocrinol. 2012 Dec;1(4):74-82.

Winston JB, Schulkey CE, Chen IB, Regmi SD, Efimova M, Erlich JM, Green CA, Aluko A, Jay PY. Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation.
Circ Cardiovasc Genet. 2012 Jun;5(3):293-300.

Krachulec J, Vetter M, Schrade A, Löbs AK, Bielinska M, Cochran R, Kyrönlahti A, Pihlajoki M, Parviainen H, Jay PY, Heikinheimo M, Wilson DB. GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice. Endocrinology. 2012 Jun;153(6):2599-611.

Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR. Gαi2 signaling: friend or foe in cardiac injury and heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):443-53.

Yang KC, Jay PY, McMullen JR, Nerbonne JM. Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure. Cardiovasc Res. 2012 Feb 1;93(2):252-62.

Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, Finck BN. Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis. J Mol Cell Cardiol. 2011 Jul;51(1):120-8.

Kyrönlahti A, Vetter M, Euler R, Bielinska M, Jay PY, Anttonen M, Heikinheimo M, Wilson DB. GATA4 deficiency impairs ovarian function in adult mice. Biol Reprod. 2011 May;84(5):1033-44.

Vyas AK, Yang KC, Woo D, Tzekov A, Kovacs A, Jay PY, Hruz PW. Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy. PLoS One. 2011 Feb 17;6(2):e17178.

Yang KC, Foeger NC, Marionneau C, Jay PY, McMullen JR, Nerbonne JM. Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy. J Physiol. 2010 Dec 15;588(Pt 24):5015-32.

Winston JB, Erlich JM, Green CA, Aluko A, Kaiser KA, Takematsu M, Barlow RS, Sureka AO, LaPage MJ, Janss LL, Jay PY. Heterogeneity of genetic modifiers ensures normal cardiac development. Circulation. 2010 Mar 23;121(11):1313-21.

Ng A, Wong M, Viviano B, Erlich JM, Alba G, Pflederer C, Jay PY, Saunders S. Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol. 2009 Nov 1;335(1):208-15.

Sabirzhanova I, Sabirzhanov B, Bjordahl J, Brandt J, Jay PY, Clark TG. Activation of Tolloid-like 1 gene expression by the cardiac specific homeobox gene Nkx2-5. Dev Growth Differ. 2009 May;51(4):403-10.

Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, Krantz I, Milbrandt J. Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PLoS One. 2009;4(5):e5232.

Jay PY. The 16th Asian Pacific Congress of Cardiology (APCC). IDrugs. 2008 Mar;11(3):181-3. No abstract available.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Patrick Y. Jay.

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Copyright 2014 Washington University School of Medicine