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Keith A. Hruska, MD

Current Position
Professor, Pediatrics
Division of Pediatric Nephrology
Professor, Medicine and Cell Biology

Specialty Areas
Pediatric Nephrology

Patients Seen At
Medicine Multispecialty Center
Center for Advanced Medicine
4921 Parkview Place, B, 5
St. Louis, MO  63110
Fax:   314-747-5213
View Campus Map   View Driving Directions

St. Louis Children's Hospital
One Children's Place, Suite C, 2nd Floor
St. Louis, MO  63110
Fax:   314-454-4283
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Pediatrics
660 S. Euclid Avenue, Campus Box 8208
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric and adult kidney disease, chronic kidney diseases, kidney stones, the CKD-MBD, vascular calcification, kidney tubulointerstitial disease, tubulointerstitial fibrosis, transplantation of neocartilage, hyperparathyroidism, calcium and phosphorus metabolism, diabetic nephropathy

Board Certification
Internal Medicine -- Certified
Nephrology -- Certified

Medical Education
B.S.: Creighton University, Omaha, Nebraska, 1965
Medical Degree: Creighton University, Omaha, Nebraska, 1969
Residency : Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, 1972
Fellowship: Nephrology, Washington University School of Medicine, St. Louis, Missouri, 1974
Hospital Affiliations
Barnes-Jewish Hospital, St. Louis
St. Louis Children's Hospital, St. Louis

Honors and Awards
Listed in Best Doctors in America, 2003-2013 (Best Doctors, Inc.)
Listed in America's Top Doctors, 2002-2012 (Castle Connolly Medical Ltd.)
President American Society Bone Mineral Research 2011-2012

Disclosure of Financial Interests with Industry
Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

Dr. Keith A. Hruska reported the following earned financial interests during calendar year 2014. Move your mouse over a header for more info.
Royalties: When a faculty member invents or conceives a new or improved process or product, the company that manufactures the product will make royalty payments to the faculty member. Royalty payments usually are a small percentage of the company’s revenue related to that product.
Consulting &
Advisory Boards
Consulting and Advisory Boards: Faculty may be paid to provide expertise to a company by being their consultant, or by serving on an advisory board.
Speaker Fees
Speaker Fees: Companies may pay faculty to speak to professional audiences about their products.
Shire  $1,000-$10,000 $1,000-$10,000 
To learn more about Washington University's policies on collaborations with industry, click here.

Editorial Responsibilities
Editorial Board: Journal Biological Chemistry
Past Editor: Calcified Tissue International, Am J. Physio. Renal

Selected or Recent Journal Articles
Sugatani T, Hruska KA. Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis. J Cell Biochem. 2013 Jun;114(6):1217-22.

Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013 May;98(5):1916-22.

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG, Herrington DM, Wagenknecht LE, Langefeld CD, Freedman BI. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013 Feb;6(1):97-105.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013 Jan;98(1):E60-5.

Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. BMC Nephrol. 2012 Nov 14;13:148.

Manson SR, Niederhoff RA, Hruska KA, Austin PF. Endogenous BMP-7 is a critical molecular determinant of the reversibility of obstruction-induced renal injuries. Am J Physiol Renal Physiol. 2011 Dec;301(6):F1293-302.

Siedlecki AM, Jin X, Thomas W, Hruska KA, Muslin AJ. RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury. Kidney Int. 2011 Aug;80(3):263-71.

Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Hruska KA, Freedman BI. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011 Jul;26(7):1554-60.

Manson SR, Niederhoff RA, Hruska KA, Austin PF. The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury. J Urol. 2011 Jun;185(6 Suppl):2523-30.

Hruska KA, Mathew S. The roles of the skeleton and phosphorus in the CKD mineral bone disorder. Adv Chronic Kidney Dis. 2011 Mar;18(2):98-104.

Sugatani T, Vacher J, Hruska KA. A microRNA expression signature of osteoclastogenesis.  Blood. 2011 Mar 31;117(13):3648-57.

Miller KM, Li S, Kaukinen KH, Ginther N, Hammill E, Curtis JM, Patterson DA, Sierocinski T, Donnison L, Pavlidis P, Hinch SG, Hruska KA, Cooke SJ, English KK, Farrell AP. Genomic signatures predict migration and spawning failure in wild Canadian salmon.
Science. 2011 Jan 14;331(6014):214-7.

Hruska KA, Hinch SG, Healey MC, Patterson DA, Larsson S, Farrell AP. Influences of sex and activity level on physiological changes in individual adult sockeye salmon during rapid senescence. Physiol Biochem Zool. 2010 Jul-Aug;83(4):663-76.

Donaldson MR, Hinch SG, Patterson DA, Farrell AP, Shrimpton JM, Miller-Saunders KM, Robichaud D, Hills J, Hruska KA, Hanson KC, English KK, Van Der Kraak G, Cooke SJ. Physiological condition differentially affects the behavior and survival of two populations of sockeye salmon during their freshwater spawning migration. Physiol Biochem Zool. 2010 May-Jun;83(3):446-58.

Hruska KA, Choi ET, Memon I, Davis TK, Mathew S. Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD). Pediatr Nephrol. 2010 Apr;25(4):769-78.

For more articles and abstracts, take this off-site link to the National Library f Medicine Pub Med page for Dr. Keith A. Hruska.

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Copyright 2015 Washington University School of Medicine