Neurological Surgery

Surgeons in the Department of Neurosurgery treat adult and pediatric patients with disorders of the nervous system, brain, meninges, skull, and blood supply, the extracranial carotid and vertebral arteries; brain tumors, disorders of the pituitary gland, disorders of the spinal cord, meninges, and vertebral column, including those which may require treatment by spinal fusion or instrumentation; and disorders of the cranial, spinal and peripheral nerves.

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Home > Physicians Directory > Neurological Surgery

Matthew D. Smyth, MD

Specialty Areas
Pediatric Neurosurgery
Epilepsy Surgery
Craniosynostosis

Areas of Clinical Interest
Pediatric neurosurgery, epilepsy, craniosynostosis, craniofacial surgery, brain tumors, neuro-endoscopy, chiari malformation, spina bifida, hydrocephalus, syringomyelia, spasticity, neurofibromatosis, tuberous sclerosis, cortical dysplasia.



Areas of Research Interest
Cortical dysplasia, animal models of epilepsy, cortical cooling for epilepsy, deep brain stimulation for epilepsy, genetic correlates of craniosynostosis

Major or Recent Publications/Awards

Honors and Awards
Listed in Best Doctors in America, 2009 (Best Doctors, Inc)
Who's Who in Medical Sciences Education, 2005
Who's Who in America, 2001
Awarded AANS National Research Education Foundation Fellowship for Investigation of Pharmacoresistance in an Animal Model of Cortical Dysplasia (declined), 2000
Principle Investigator, NIH National Research Service Award, Grant #1 F32 NS11067-01: Investigation of Pharmacoresistance in an Animal Model of Cortical Dysplasia

Editorial Responsibilities
Ad hoc Reviewer
Archives of Physical Medicine and Rehabilitation
Clinical Anatomy
Epilepsia
Epilepsy and Behavior
Journal of Neurosurgery
Journal of Pediatrics
Neurosurgery

Invited Publications

Smyth MD and Rubin J. Ependymoma. Pediatric CNS Tumors, second edition. Gupta N, Banerjee A, Haas-Kogan D (eds), Springer-Verlag, Heidelberg, Germany, in preparation, 2008.

Smyth MD, Marchac D. Renier D. Syndromic Craniosynostosis: Open Surgery. Youman’s Textbook of Neurological Surgery, 6th edition. Winn HR (ed). Elsevier, in press, 2008.

Limbrick DD, Smyth MD. Vagal Nerve Stimulation. Pediatric Epilepsy Surgery: Preoperative Assessment and Surgical Treatment. Catalepe O, Jallo G (eds). Thieme Publishers, in press, 2008.

Shah MM, Smyth MD. Increased Intracranial Pressure. Pediatric Primary Care, 5th edition. American Academy of Pediatrics Department of Publications, in press, 2008.

Johnston JM, Smyth MD, McKinstry RC. Basics of Neuroimaging in Pediatric Epilepsy. Pediatric Epilepsy: Diagnosis and Therapy, Third Edition, Pellock, Dodson, Bourgeois, Nordli, Sankar (eds), 2008.

Ojemann SG, Smyth MD, and Peacock WJ. Functional Neurosurgery in the Child, Handbook of Pediatric Neurosurgery, Frim DM and Gupta N (eds), Landes Bioscience, Georgetown TX, 2006.

Horn BN and Smyth MD. Ependymoma. Pediatric CNS Tumors, Gupta N, Banerjee A, Haas-Kogan D (eds), Springer-Verlag, Heidelberg, Germany, 2004.

Zakhary R, Smyth MD and Peacock WJ. Dorsal Rhizotomy for Spasticity. Handbook of Stereotactic and Functional Neurosurgery, M Schulder (ed), Marcel Dekker, Inc., New York, NY, Feb 2003.

Ojemann SG, Smyth MD, and Peacock WJ. Functional Neurosurgery in the Child. Handbook of Pediatric Neurosurgery, Frim DM and Gupta N (eds), Landes Bioscience, Georgetown TX, 2003.

Peacock WJ and Smyth MD. Selective Dorsal Rhizotomy Spasticity of the Peripheral Nervous System. Textbook of Neurological Surgery - Principles of Practice, HH Bather, CM Loftus, TH Weinzerl (eds), Lippincott-Raven Publishers, Philadelphia, PA 2002

Selected Journal Articles

Zhang D, Johnston JM, Fox MD, Leuthardt E, Grubb RL, Chicoine MR, Smyth MD, Snyder AZ, Raichle ME, Shimony JS. Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with fMRI: Initial experience. In press, Neurosurgery, 2009.

Limbrick DD, Narayan P, Powers AK, Johnston J, Ojemann JG, Park TS, Bertrand M, Smyth MD. Hemispherotomy: efficacy and analysis of seizure recurrence. Accepted with revisions, Journal of Neurosurgery: Pediatrics, 2009.

Smyth MD. Comment: Acute ventriculoperitoneal shunt malfunction following opening of the spinal subarachnoid space. Child’s Nervous System, Epub ahead of print, Jan 29, 2009.

Berlach DJ, Gurnett CA, Limpaphyayom N, Alaee F, Zang Z, Porter KR, Kirchofer ML, Smyth MD, Dobbs MB: Early results of the Ponseti method for the treatment of clubfoot associated with myelomeningocele. Accepted, with revisions, Journal of Bone and Joint Surgery, 2008.

Smyth MD, Limbrick DD, Behdad A, Bertrand M. Epilepsy surgery in children with seizures arising from the Rolandic cortex. (Abstract) Child’s Nervous System, 24 1227, 2008.

Reynolds MR, Blackburn SL, Smyth MD. Ossified pseudomeningocele following Chiari decompression in a patient with Kleeblattshädel deformity: Case report and review of the literature. Journal of Neurosurgery: Pediatrics 2:203-06, 2008.

Behdad A, Limbrick DL, Bertrand M, Smyth MD. Epilepsy surgery in children with seizures arising from the Rolandic cortex. In press, Epilepsia, August 2008.

He BJ, Snyder AZ, Zempel JM, Smyth MD, Raichle ME. Electrophysiological correlates of the brain’s intrinsic large-scale functional architecture. Proceedings of the National Academy of Sciences, 105(41):16039-44, 2008.

Miller, JH, Limbrick DL, Callen M, Smyth, MD. Spontaneous resolution of type I Chiari malformation in monozygotic twins. Journal of Neurosurgery: Pediatrics 2:317-19, 2008.

Johnston JM, Vaishnavi SN, Smyth MD, He BJ, Zhang DY, Zempel JM, Shimony JS, Snyder AZ, Raichle ME. Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum. Journal of Neuroscience, 18:28(25):6453-8, 2008.

Wisneski KJ, Anderson NR, Blakely TM, Schalk G, Smyth MD, Morrisey M, Zempel J, Dowling J, Moran DW, Leuthardt EC. The unique cortical physiology associated with ipsilateral hand movements and neuroprosthetic implications. In press, Stroke, 2008.

Shah M, Smyth MD, Woo A. Adverse facial edema associated with off-label use of rh-BMP-2 in cranial reconstruction for craniosynostosis: case report. Journal of Neurosurgery: Pediatrics, 1:255-257, 2008

Smith MD, Narayan P, Tubbs RS, Leonard JR, Park TS, Loukas M, Grabb PA. Cumulative diagnostic radiation exposure in children with ventriculoperitoneal shunts: a review. Child’s Nervous System, 24(4):493-7, 2008.

Schalk G, Miller KJ, Anderson NR, Wilson JA, Smyth MD, Ojemann JG, Moran DW, Wolpaw JR, Leuthhardt EC. Two-dimensional movement control using electrocorticographic signals in humans. Journal of Neural Engineering, 5:75-84, 2008.

Smyth MD, Limbrick D, Ojemann JG, Zempel J, Robinson S, O'Brien DF, Saneto RP, Goyal M, Appleton RE, Park TS. Outcome following surgery for temporal lobe epilepsy in pre-adolescent children with hippocampal pathology: emphasis on mesial temporal sclerosis. Journal of Neurosurgery:Pediatrics, 106:205-210, 2007.

Johnston J, Vyas N, Kane AA, Molter D, Smyth MD: Giant intracranial teratoma with epignathus in a neonate: Case report and review of the literature. Journal of Neurosurgery:Pediatrics, 106:232-236, 2007.

Seto ML, Hing AV, Chang JC, Hu M, Kapp-Simon KA, Patel PK, Burton BK, Kane AA, Smyth MD, Hopper R, Ellenbogen RG, Stevenson K, Speltz ML, Cunningham ML. Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations. American Journal of Medical Genetics Part A, 143A: 678-686, 2007.

Smyth MD, Klein E, Dodson WE, Mansur D: Radiosurgical posterior corpus callosotomy in a child with Lennox-Gastaut syndrome. Journal of Neurosurgery:Pediatrics, 106(4):312-315, 2007.

Blackburn SL, Smyth MD. Hydrogel-induced cervico-medullary compression after posterior fossa decompression for Chiari malformation: Case report. Journal of Neurosurgery:Pediatrics, 106(4):302-304, 2007.

Refai D, Perrin R, Smyth MD: Iatrogenic intraspinal epidermoid cyst: Case illustration. Journal of Neurosurgery:Pediatrics, 106(4):32, 2007.

Limbrick DD, Narayan P, Johnston JM, Ojemann JG, Park TS, Smyth MD: Outcomes following hemispherotomy: the St. Louis Children’s Hospital experience. (Abstract) Child’s Nervous System, 23(9):1062, 2007.

O’Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD and Park TS. The Children’s Cancer and Leukaemia Group Guidelines for the Diagnosis and Management of Dysembryoplastic Neuroepithelial Tumours. British Journal of Neurosurgery, 21(6):539-49, 2007.

Johnston MJ Jr., Mangano FT, Ojemann JG, Park TS, Trevathan E, Smyth MD. Complications of invasive subdural grid and strip electrode monitoring at Saint Louis Children’s Hospital, 1994-2005. Journal of Neurosurgery: Pediatrics, 105:343-347, 2006.

Smyth MD, Tennenbaum MJ, Kaufman C, Kane AA. ‘Clamshell Craniotomy’: a technique for previously uncorrected sagittal craniosynostosis in older children. Journal of Neurosurgery: Pediatrics 105:245-51, 2006. (cover article)

Smyth MD, Narayan P, Tubbs RS, Leonard J, Park TS, Grabb PA. Potential association of malignancy and repeat diagnostic CT in children with ventriculoperitoneal shunts: report of two cases. Journal of Pediatric Neurology 4(3):195-201, 2006.

Mangano FT, Menendez J, Smyth MD, Leonard JR, Park TS. Neurosurgical injuries associated with all-terrain vehicles in pediatric patients: A ten year experience at St. Louis Children’s Hospital. Journal of Neurosurgery: Pediatrics, 105(1):2-5, 2006.

Mangano FT, Limbrick D, Leonard JR, Park TS, Smyth MD. Simultaneous image-guided and endoscopic navigation without rigid skull fixation: application in infants: technical case report. Neurosurgery 58 (4 Suppl 2) ONS-E377; discussion ONS-E377, 2006.

Smyth MD, Burton JM, Peebles GA, Binder DK, Rothman SR. Transcortical cooling inhibits hippocampal-kindled seizures in the rat. (Abstract) Epilepsia, 46(8):302, 2005.

Smyth MD, Ojemann JG, Zempel J, Robinson S, O'Brien DF, Saneto RP, Goyal M, Appleton RE, Park TS. Surgical outcomes for temporal lobe epilepsy in young children: A multi-institution analysis. (Abstract) Epilepsia 2005; 46(8):158.

Rothman SM, Smyth MD, Yang XF, Peterson GP. Focal cooling for epilepsy: An alternative therapy that might actually work. Epilepsy and Behavior 2005; 7:214-221.

Ashley WW, McKinstry RC, Leonard JR, Smyth MD, Lee BC, Park TS. Utility of rapid-sequence MRI for evaluation of hydrocephalus in children. Journal of Neurosurgery: Pediatrics 2005; 103:124-130.

Mangano FT, Menendez J, Leonard JR, Park TS, Smyth MD. Early programmable valve failure in pediatric hydrocephalus. Journal of Neurosurgery: Pediatrics 2005;103:501-507.

Burton J, Peebles G, Binder DK, Rothman SM, Smyth MD. Transcortical cooling inhibits hippocampal-kindled seizures in the rat. Epilepsia 2005; 46:1881-1887.

Tubbs RS, Banks JT, Soleau S, Smyth MD, Wellons JC, Blount JP, Grabb PA and Oakes WJ. Complications of the ventriculosubgaleal shunt in pediatric neurosurgery. Child's Nervous System 2005; 21:48-51.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Matthew D. Smyth

Matthew D. Smyth, MD