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Neurology / Pediatric

Jean Holowach Thurston, MD

Current Position
Professor Emerita of Pediatrics and Neurology

Specialty Areas
Pediatric Neurology
Neurology - General

Patients Seen At
St. Louis Children's Hospital
One Children's Place, Suite D, Floor 2
St. Louis, MO  63110
314-454-6120
Fax:   314-454-2523
View Driving Directions

Mailing Address
Department of Neurology
Washington University School of Medicine
660 South Euclid Ave.
Campus Box: 8111
St. Louis, MO  63110

Board Certification
Pediatrics -- Certified

This physician is not able to accept new patients at this time.

Medical Education
B.A.: University of Alberta, Edmonton, Alberta, Canada, 1938
Medical Degree: University of Alberta, Edmonton, Alberta, Canada, 1941
Rotating Internship: University of Alberta Hospital, Alberta, Canada, 1941
Senior Internship: Pediatrics, Holy Cross Hospital, Calgary, 1942
Fellowship: Pediatric Metabolism, Washington University School of Medicine, St. Louis, Missouri, 1946
Fellowship: Neurochemistry, Washington University School of Medicine, St. Louis, Missouri, 1965
Hospital Affiliations
St. Louis Children's Hospital

Honors and Awards
Formon-Peterson Founders Award, by Midwest Society for Pediatric Research, 1990

Neurological Disorders Program, Project Review B Committee, 1974-1987

Consultant, Technical Merit Review Committee Comprehensive Epilepsy Program, NINCDS, 1975, 1982

Member, Committee of the Pediatric Division of the Southwest Cancer Chemotherapy Group Study Group, 1960-1962

Editorial Responsibilities
Editorial Board
Metabolic Brain Disease

Selected or Recent Journal Articles
Thurston JH, Hauhart RE. Comparative effects of valproate and the new experimental anticonvulsant drug alpha-ethyl-alpha-methyl-thiobutyrolactone on selected metabolite levels in the plasma, livers, and brains of infant mice. Epilepsia. 1996 Jan;37(1):2-5.

Thurston JH, McDougal DB Jr, Hauhart RE, Schulz DW. Effects of acute, subacute, and chronic diabetes on carbohydrate and energy metabolism in rat sciatic nerve. Relation to mechanisms of peripheral neuropathy. Diabetes. 1995 Feb;44(2):190-5.

Thurston JH, Hauhart RE. Reversal of the adverse chronic effects of the unsaturated derivative of valproic acid--2-n-propyl-4-pentenoic acid--on ketogenesis and liver coenzyme A metabolism by a single injection of pantothenate, carnitine, and acetylcysteine in developing mice. Pediatr Res. 1993 Jan;33(1):72-6.

Thurston JH, Hauhart RE. Amelioration of adverse effects of valproic acid on ketogenesis and liver coenzyme A metabolism by cotreatment with pantothenate and carnitine in developing mice: possible clinical significance. Pediatr Res. 1992 Apr;31(4 Pt 1):419-23.

Thurston JH, Hauhart RE. Valproate doubles the anoxic survival time of normal developing mice: possible relevance to valproate-induced decreases in cerebral levels of glutamate and aspartate, and increases in taurine. Life Sci. 1989;45(1):59-62.

Thurston JH, Sherman WR, Hauhart RE, Kloepper RF. myo-inositol: a newly identified nonnitrogenous osmoregulatory molecule in mammalian brain. Pediatr Res. 1989 Nov;26(5):482-5.

Thurston JH, Hauhart RE. Effect of momentary stress on brain energy metabolism in weanling mice: apparent use of lactate as cerebral metabolic fuel concomitant with a decrease in brain glucose utilization. Metab Brain Dis. 1989 Sep;4(3):177-86.

Thurston JH, Hauhart RE, Nelson JS. Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain. Metab Brain Dis. 1987 Dec;2(4):223-41.

Rothman SM, Thurston JH, Hauhart RE. Delayed neurotoxicity of excitatory amino acids in vitro. Neuroscience. 1987 Aug;22(2):471-80.

Thurston JH, Hauhart RE, Dirgo JA, Schulz DW. Effects of acute hyperosmolar NaCl or urea on brain H2O, Na+, K+, carbohydrate, and amino acid metabolism in weanling mice: NaCl induces insulin secretion and hypoglycemia. Metab Brain Dis. 1986 Jun;1(2):129-46.

Thurston JH, Hauhart RE, Schiro JA. Beta-hydroxybutyrate reverses insulin-induced hypoglycemic coma in suckling-weanling mice despite low blood and brain glucose levels. Metab Brain Dis. 1986 Mar;1(1):63-82.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Jean Holowach Thurston.


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Copyright 2014 Washington University School of Medicine