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Neurology / Pediatric

Michael Wong, MD, PhD

Current Position
Associate Professor, Neurology, Pediatrics, and Neurobiology
Division of Pediatric Neurology
Director, Tuberous Sclerosis Clinic

Specialty Areas
Pediatric Neurology
Pediatric Epilepsy

Patients Seen At
St. Louis Children's Hospital
One Children's Place, Suite D, Floor 2
St. Louis, MO  63110
Fax:   314-454-4225
View Driving Directions

Mailing Address
Department of Neurology
Washington University School of Medicine
660 South Euclid Ave.
Campus Box: 8111
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric neurology, tuberous sclerosis, epilepsy in children

Board Certification
Pediatric Neurology -- Certified
Neurology -- Certified
Clinical Neurophysiology -- Certified

Medical Education
B.A.: Biology, Princeton University, Princeton, New Jersey, 1987
Medical Degree: University of Texas Southwestern Medical School, Dallas, Texas, 1995
Ph.D.: Neuroscience, University of Texas Southwestern Graduate School, Dallas, Texas, 1995
Residency: Pediatric Neurology, Barnes-Jewish Hospital at Washington University School of Medicine, St. Louis, Missouri, 1999
Fellowship: Pediatric Epilepsy, Washington University School of Medicine, St. Louis, Missouri, 2001
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital

Honors and Awards
Listed in Best Doctors in America, 2006-2013 (Best Doctors, Inc.)
American Epilepsy Society, 2001-present
American Academy of Neurology, 1998-present
Society for Neuroscience, 1989-present

Editorial Responsibilities
Ad Hoc Reviewer
Clinical Neurophysiology

Reviews and Chapters
Wong M, Mink JW. Cellular Neurophysiolog. In: Textbook of Neurosurgery: Principles and Practice. Batjer, Loftus eds. New York: Lippincott Williams & Wilkins, 2003, In Press

Wong M, Trevathan E. Infantile spasms. Pediatric Neurol 2001; 24:89-98

Moss RL, Gu Q, Wong M. Estrogen: Nontranscriptional signaling pathway. Recent Progress Horm Res 1997; 52:33-69

Wong M, Moss RL. Nongenomic actions of estrogen in the brain: Physiological significance and cellular mechanisms. Crit Rev Neurobiol 1996; 10:189-203

Shakkottai VG, Xiao M, Xu L, Wong M, Nerbonne JM, Ornitz DM, Yamada KA. FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons. Neurobiol Dis 2009; 33:81-88. PMID: 18930825

Zeng LH, Rensing NR, Wong M. The mammalian target of rapamycin (mTOR) signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci 2009; in press.

Xu L, Wong M. Seizure-related changes in dendritic spine structure. Encyclopedia of Basic Epilepsy Research 2009; in press.

Zeng LH, Gutmann DH, Wong M. Glial-mediated mechanisms of epileptogenesis in tuberous sclerosis. Encyclopedia of Basic Epilepsy Research, 2009; in press.

Wong M. Astrocyte networks and epilepsy: when stars collide. Epilepsy Curr 2009; in press.

Xu L, Rensing N, Yang XF, Zhang HX, Thio LL, Rothman SM, Weisenfeld AE, Wong M, Yamada KA. Leptin inhibits 4-aminopyridine- and penetyelentetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J Clin Investigation 2008; 118:272-280. PMID: 18097472

Erbayat-Altay E, Yamada KA, Wong M, Thio LL. Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice. Neurosci Lett 2008; 433;82-86. PMID: 18241989

Zeng LH, Xu L, Gutmann DH, Wong M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol 2008; 63:444-453. PMID: 18389497

Wong M. Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development. Epilepsia 2008; 49:8-21. PMID: 17727667

Wong M. Stabilizing dendritic structure as a novel therapeutic approach for epilepsy. Expert Rev Neurotherapeutics 2008; 8:907-915. PMID: 18505356

Rensing NR, Ouyang Y, Yang XF, Yamada KA, Rothman SM, Wong M. In vivo imaging of dendritic spines during electrographic seizures. Ann Neurol 2005; 58:888-898

Wong M. Modulation of dendritic spines in epilepsy: cellular mechanisms and functional implications. Epilepsy & Behav 2005; 7:569-577

Jansen LA, Uhlmann EJ, Gutmann DH, Wong M. Epileptogenesis and reduced inward rectifier potassium current in Tuberous Sclerosis Complex-1 deficient astrocytes. Epilepsia 2005; 46:1871-1880

Wong M, Ess KE, Uhlmann EJ, Jansen LA, Li W, Crino PB, Mennerick S, Yamada KA, Gutmann DH. Impaired astrocyte glutamate transport in a mouse epilepsy model of tuberous sclerosis complex. Ann Neurol 2003; 54:251-256

Wong M, Wozniak M, Yamada KA. An animal model of generalized non-convulsive status epilepticus: Immediate characteristics and long-term effects. Exp Neurol 2003; 183:87-99

Wong M, Ess K, Landt M. Cerebrospinal fluid neuron-specific enolase following seizures in children: Role of etiology. J Child Neurol 2002; 17:261-264

Wong M, Schlaggar BL, Landt M. Postictal cerebrospinal fluid abnormalities in children. J Pediatr 2001; 138:373-377

Wong M, Schlaggar BL, Buller RS, Storch GA, Landt M. Cerebrospinal fluid protein in pediatric patients: Defining clinically-relevant reference values. Arch Pediatr Adolescent Med 2000; 154:827-831

Landt M, Parvin CA, Wong M. Leptin concentrations in cerebrospinal fluid from children. Clin Chem 2000; 46:854-858

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Michael Wong

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Copyright 2014 Washington University School of Medicine