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Internal Medicine / Oncology

Gerald P. Linette, MD, PhD

Current Position
Associate Professor, Medicine and Neurosurgery
Division of Oncology

Specialty Areas
Brain Tumors
Neuro Oncology
Medical Oncology
Skin Cancer

Patients Seen At
Center for Advanced Medicine
Neuroscience Center
4921 Parkview Place, Suite C, 6th Floor
St. Louis, MO  63110
Fax:   314-362-7086
View Floor Map  View Campus Map   View Driving Directions

Siteman Cancer Center
Center for Advanced Medicine
4921 Parkview Place, Suite B, 7th Floor
St. Louis, MO  63110
Fax:   314-362-7086
View Floor Map  View Campus Map   View Driving Directions

Mailing Address
Washington University School of Medicine
Division of Oncology
660 South Euclid Avenue, Campus Box 8056
St. Louis, MO  63110

Areas of Clinical Interest
Melanoma, Brain tumors, Neuro-oncology, Medical Oncology

Areas of Research Interest
Immunological approaches for the treatment of cancer

Board Certification
Internal Medicine -- Certified
Medical Oncology -- Certified

Medical Education
B.S.: Biology, St. Joseph's University, Philadelphia, Pennsylvania, 1980
Medical Degree/PhD: Microbiology, Georgetown University School of Medicine, Washington DC, 1990
Residency: Barnes Hospital, St. Louis, Missouri, 1992
Fellowship: Research, Molecular Oncology, Washington University School of Medicine, St. Louis, Missouri, 63110, 1995
Fellowship: Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts, 1998
Hospital Affiliations
Barnes-Jewish Hospital

Honors and Awards
Listed in Best Doctors in America, 2005-2013 (Best Doctors, Inc.)

Editorial Responsibilities

Ad Hoc Reviewer
International Journal of Cancer
Clinical Cancer Research

Selected or Recent Journal Articles
Lin AL, Liu J, Evans J, Leuthardt EC, Rich KM, Dacey RG, Dowling JL, Kim AH, Zipfel GJ, Grubb RL, Huang J, Robinson CG, Simpson JR, Linette GP, Chicoine MR, Tran DD. Codeletions at 1p and 19q predict a lower risk of pseudoprogression in oligodendrogliomas and mixed oligoastrocytomas. Neuro Oncol. 2014 Jan;16(1):123-30.

Carreno BM, Becker-Hapak M, Huang A, Chan M, Alyasiry A, Lie WR, Aft RL, Cornelius LA, Trinkaus KM, Linette GP. IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity. J Clin Invest. 2013 Aug 1;123(8):3383-94.

Linette GP, Stadtmauer EA, Maus MV, Rapoport AP, Levine BL, Emery L, Litzky L, Bagg A, Carreno BM, Cimino PJ, Binder-Scholl GK, Smethurst DP, Gerry AB, Pumphrey NJ, Bennett AD, Brewer JE, Dukes J, Harper J, Tayton-Martin HK, Jakobsen BK, Hassan NJ, Kalos M, June CH. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Blood. 2013 Aug 8;122(6):863-71.

Kolar GR, Miller-Thomas MM, Schmidt RE, Simpson JR, Rich KM, Linette GP. Neoadjuvant treatment of a solitary melanoma brain metastasis with vemurafenib. J Clin Oncol. 2013 Jan 20;31(3):e40-3

Carreno BM, Becker-Hapak M, Chan M, Lie WR, Wang X, Hansen TH, Linette GP. Amino-terminal extended peptide single-chain trimers are potent synthetic agonists for memory human CD8+ T cells. J Immunol. 2012 Jun 15.

Creach KM, Rubin JB, Leonard JR, Limbrick DD, Smyth MD, Dacey R, Rich KM, Dowling JL, Grubb RL Jr, Linette GP, King AA, Michalski JM, Park TS, Perry A, Simpson JR, Mansur DB. Oligodendrogliomas in children. J Neurooncol. 2012 Jan.

Carreno BM, Garbow JR, Kolar GR, Jackson EN, Engelbach JA, Becker-Hapak M, Carayannopoulos LN, Piwnica-Worms D, Linette GP. Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases. Clin Cancer Res. 2009 May 15.

Dayani PN, Gould JE, Brown DB, Sharma KV, Linette GP, Harbour JW. Hepatic metastasis from uveal melanoma: angiographic pattern predictive of survival after hepatic arterial chemoembolization. Arch Ophthalmol. 2009 May.

Carreno BM, Becker-Hapak M, Linette GP. CD40 regulates human dendritic cell-derived IL-7 production that, in turn, contributes to CD8(+) T-cell antigen-specific expansion. Immunol Cell Biol. 2009 Feb.

Fracasso PM, Picus J, Wildi JD, Goodner SA, Creekmore AN, Gao F, Govindan R, Ellis MJ, Tan BR, Linette GP, Fu CJ, Pentikis HS, Zumbrun SC, Egorin MJ, Bellet RE. Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin, in resistant solid tumor malignancies. Cancer Chemother Pharmacol. 2009 Feb.

Truscott SM, Wang X, Lybarger L, Biddison WE, McBerry C, Martinko JM, Connolly JM, Linette GP, Fremont DH, Hansen TH, Carreno BM. Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides. J Biol Chem. 2008 Mar 21.

Sharma KV, Gould JE, Harbour JW, Linette GP, Pilgram TK, Dayani PN, Brown DB. Hepatic arterial chemoembolization for management of metastatic melanoma. AJR Am J Roentgenol. 2008 Jan.

Linette GP, Carlson JA, Slominski A, Mihm MC, Ross JS. Biomarkers in melanoma: stage III and IV disease. Expert Rev Mol Diagn. 2005 Jan.

Jonasch E, Kumar U, Linette GP, Hodi FS, Soiffer RJ, Ryan BF, Sober AJ, Mihm MA, Tsao H, Langley RG, Cosimi BA, Gadd MA, Tanabe KK, Souba W, Haynes HA, Barnhill R, Osteen R and Haluska FG. A single program experience with adjuvant high-dose interferon alfa-2b for high risk melanoma. Cancer J Sci Am 2000.

Yang S, Linette GP, Longerich S, Roberts BL and Haluska FG. HLA-A2.1/Kb transgenic murine dendritic cells transduced with adenovirus encoding human gp 100 process the same A2.1-restricted peptide epitopes as human antigen presenting cells and elicit A2.1-restricted peptide specific CTL. Cell Immunol 2000.

Linette GP, Shankara S, Longerich S, Yang S, Doll R, Nicolette C, Preffer FI, Roberts B and Haluska FG. In vitro priming with adenovirus/gp 100 antigen transduced dendritic cells reveals the specificity fo HLA-A*0201 restricted CD8+ T cells in patients with melanoma. J Immunol 2000.

Linette GP, Li Y, Roth K and Knrsmeyer SJ. Cross talk between cell death and cell cycle progression: Bcl-2 regulates NFAT-mediated activation. Proc Natl Acad Sci U S A. 1996 Sep 3.

Chao DT, Linette GP, Boise LH, White LS, Thompson CB, Korsmeyer SJ. Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med. 1995 Sep 1.

Linette GP, Hess JL, Sentman CL, Korsmeyer SJ. Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice. Blood. 1995 Aug 15.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Gerald Linette.

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Copyright 2015 Washington University School of Medicine