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Surgery / General Surgery - Transplantation

William C. Chapman, MD, FACS

Current Position
Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas
Transplantation Surgery
Liver Surgery
Pediatric Liver Transplantation
Hepatobiliary Surgery
Liver Transplantation
Liver Diseases

Additional Features and Interviews with Dr. Chapman:

Ask the Expert - Ladue News: Transplantation for Liver Cancer

Featured Physician

Patients Seen At
Center for Advanced Medicine
GI Center
4921 Parkview Place, C, 8
St. Louis, MO  63110
(314) 362-2538
Fax:   314-361-4197
View Floor Map  View Campus Map   View Driving Directions

Mailing Address
Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8109
St. Louis, MO  63110

Areas of Clinical Interest
Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

Areas of Research Interest
Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention

Board Certification
Critical Care -- Certified
General Surgery -- Certified

Medical Education
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina, 1980
Medical Degree: Medical University of South Carolina, Charleston, South Carolina, 1984
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee, 1987
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee, 1989
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee, 1991
Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England, 1992
Hospital Affiliations
Barnes-Jewish Hospital
St Louis Children's Hospital
St. Louis Veteran’s Administration Medical Center

Honors and Awards
Listed in Best Doctors in America, 2005-2013 (Best Doctors, Inc.)
Listed in America's Top Doctors, 2003-2012 (Castle Connolly Medical Ltd.)
J. Bradley Aust Award, Western Surgical Association, 1999

Editorial Responsibilities
Annals of Surgery – Editorial Board, 2007-Present
Journal of American College of Surgeons - Editorial Board, 2005-Present
Journal of Surgical Research – Editorial Board, 2003-Present
Transplantation – Editorial Board, 2004-Present

Selected or Recent Journal Articles
Pitt SC, Vachharajani N, Doyle MB, Lowell JA, Chapman WC, Anderson CD, Shenoy S, Wellen JR. Organ allocation in pediatric renal transplants: is there an optimal donor? Clin Transplant. 2013 Nov 13.

Chen CC, Chapman W. Intraoperative Visualization of Hepatocellular Carcinoma with Indocyanine Green: Revealing the Mechanisms behind the Glowing Tumor. Ann Surg Oncol. 2013 Nov 12.

Liu TC, Vachharajani N, Chapman WC, Brunt EM. Noncirrhotic hepatocellular carcinoma: derivation from hepatocellular adenoma? Clinicopathologic analysis. Mod Pathol. 2013 Sep 20.

Angaswamy N, Tiriveedhi V, Banan B, Benshoff N, Chapman W, Mohanakumar T. Synergism of a natural plant product, oleanolic acid with calcineurin inhibitor in prolonging islet allograft survival. Transpl Immunol. 2013 Sep 12.

Reinhardt SW, Jin LX, Pitt SC, Earl TM, Chapman WC, Doyle MB. Bouveret's Syndrome Complicated by Classic Gallstone Ileus: Progression of Disease or Iatrogenic? J Gastrointest Surg. 2013 Nov.

Ramachandran S, Ilias Basha H, Sarma NJ, Lin Y, Crippin JS, Chapman WC, Mohanakumar T. Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis. PLoS One. 2013 Aug 12.
Fowler KJ, Sheybani A, Parker RA 3rd, Doherty S, M Brunt E, Chapman WC, Menias CO. Combined hepatocellular and cholangiocarcinoma (biphenotypic) tumors: imaging features and diagnostic accuracy of contrast-enhanced CT and MRI. AJR Am J Roentgenol. 2013 Aug.

Subramanian V, Bharat A, Vachharajani N, Crippin J, Shenoy S, Mohanakumar T, Chapman WC. Perioperative blood transfusion affects hepatitis C virus (HCV)-specific immune responses and outcome following liver transplantation in HCV-infected patients. HPB (Oxford). 2013 Jul 22.

Fowler KJ, Karimova EJ, Arauz AR, Saad NE, Brunt EM, Chapman WC, Heiken JP. Validation of organ procurement and transplant network (OPTN)/united network for organ sharing (UNOS) criteria for imaging diagnosis of hepatocellular carcinoma. Transplantation. 2013 Jun 27.

Doyle MB, Maynard E, Lin Y, Vachharajani N, Shenoy S, Anderson C, Earl M, Lowell JA, Chapman WC. Outcomes with split liver transplantation are equivalent to those with whole organ transplantation. J Am Coll Surg. 2013 Jul.

Ma C, Crippin JS, Chapman WC, Korenblat K, Vachharajani N, Gunter KL, Brunt EM. Parenchymal alterations in cirrhotic livers in patients with hepatopulmonary syndrome or portopulmonary hypertension. Liver Transpl. 2013 Jul.

Sarma NJ, Tiriveedhi V, Subramanian V, Shenoy S, Crippin JS, Chapman WC, Mohanakumar T. Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway. PLoS One. 2012.

Sarma NJ, Tiriveedhi V, Ramachandran S, Crippin J, Chapman W, Mohanakumar T. Modulation of immune responses following solid organ transplantation by microRNA. Exp Mol Pathol. 2012 Dec.

Cavaness KM, Doyle MB, Lin Y, Maynard E, Chapman WC. Using ALPPS to induce rapid liver hypertrophy in a patient with hepatic fibrosis and portal vein thrombosis. J Gastrointest Surg. 2013 Jan.

Tiriveedhi V, Conzen KD, Liaw-Conlin J, Upadhya G, Malone J, Townsend RR, Kerns R, Jia J, Csontos K, Ramachandran S, Mohanakumar T, Anderson CD, Chapman WC. The role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: a proteomic study. BMC Biochem. 2012 Sep 10.

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Copyright 2015 Washington University School of Medicine