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Paul W. Hruz, MD, PhD

Current Position
Associate Professor, Pediatrics
Division of Pediatric Endocrinology and Metabolism
Associate Professor, Cell Biology & Physiology
Director, Division of Pediatric Endocrinology & Diabetes

Specialty Areas
Pediatric Endocrinology
Pediatric Diabetes

Patients Seen At
St Louis Children's Hospital
One Children's Place, Suite D, 2nd Floor
St. Louis, MO  63110
Fax:   314-454-6225
View Driving Directions

Mailing Address
Washington University School of Medicine
660 S. Euclid Avenue, Campus Box: 8116
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric endocrinology, pediatric metabolism

Board Certification
Pediatrics -- Certified
Pediatric Endocrinology & Metabolism -- Certified

Medical Education
Medical Degree: Medical College of Wisconsin, Milwaukee, Wisconsin , 1993
Residency: Pediatrics, University of Washington School of Medicine, Seattle, Washington, 1997
Fellowship: Pediatric Endocrinology, Washington University School of Medicine, St. Louis, Missouri, 2000
Hospital Affiliations
St. Louis Children's Hospital

Editorial Responsibilities:
Ad Hoc Reviewer
AIDS Research and Human Retroviruses
American Journal of Pathology
American Journal of Physiology
British Journal of Pharmacology
Circulation Research
Clinical Pharmacology & Therapeutics
Comparative Biochemistry and Physiology
Future Virology
Journal of Antimicrobial Chemotherapy
Journal of Biological Chemistry
Journal of Clinical Endocrinology & Metabolism
Journal of Molecular and Cellular Cardiology
Obesity Research

Selected or Recent Journal Articles
Vyas AK, Aerni-Flessner LB, Payne MA, Kovacs A, Jay PY, Hruz PW. Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy. Cardiovasc Endocrinol. 2012 Dec;1(4):74-82.

Aerni-Flessner L, Abi-Jaoude M, Koenig A, Payne M, Hruz PW. GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle. Cardiovasc Diabetol. 2012 Jun 8;11:63.

Remedi MS, Agapova SE, Vyas AK, Hruz PW, Nichols CG. Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes. Diabetes. 2011 Oct;60(10):2515-22.

Hruz PW. Molecular mechanisms for insulin resistance in treated HIV-infection. Best Pract Res Clin Endocrinol Metab. 2011 Jun;25(3):459-68.

Hruz PW, Yan Q, Tsai L, Koster J, Xu L, Cihlar T, Callebaut C. GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system. Antimicrob Agents Chemother. 2011 Apr;55(4):1377-82.

Vyas AK, Yang KC, Woo D, Tzekov A, Kovacs A, Jay PY, Hruz PW. Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy. PLoS One. 2011 Feb 17;6(2):e17178.

Hresko RC, Hruz PW. HIV protease inhibitors act as competitive inhibitors of the cytoplasmic glucose binding site of GLUTs with differing affinities for GLUT1 and GLUT4. PLoS One. 2011;6(9):e25237.

Gazit V, Weymann A, Hartman E, Finck BN, Hruz PW, Tzekov A, Rudnick DA. Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology. 2010 Dec;52(6):2109-17.

Vyas AK, Koster JC, Tzekov A, Hruz PW. Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice. J Biol Chem. 2010 Nov 19;285(47):36395-400.

Guo W, Wong S, Pudney J, Jasuja R, Hua N, Jiang L, Miller A, Hruz PW, Hamilton JA, Bhasin S. Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2028-32.

Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W. Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes. 2009 Aug;58(8):1739-48.

Flint OP, Noor MA, Hruz PW, Hylemon PB, Yarasheski K, Kotler DP, Parker RA, Bellamine A. The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: cellular mechanisms and clinical implications. Toxicol Pathol. 2009 Jan;37(1):65-77.

Hruz PW. HIV protease inhibitors and insulin resistance: lessons from in-vitro, rodent and healthy human volunteer models. Curr Opin HIV AIDS. 2008 Nov;3(6):660-5.

Hruz PW, Yan Q, Struthers H, Jay PY. HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy. FASEB J. 2008 Jul;22(7):2161-7.

Hruz PW. Molecular Mechanisms for Altered Glucose Homeostasis in HIV Infection. Am J Infect Dis. 2006;2(3):187-192.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Paul W. Hruz.

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Copyright 2015 Washington University School of Medicine