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David A. Rudnick, MD, PhD

Current Position
Asociate Professor, Pediatrics
Division of Pediatric Gastroenterology and Nutrition

Specialty Areas
Pediatric Gastroenterology

Patients Seen At
St. Louis Children's Hospital
One Children's Place, 2nd Floor, Suite C
St. Louis, MO  63110
Fax:   314-454-2412
View Driving Directions

Mailing Address
Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8116
St. Louis, MO  63110

Areas of Clinical Interest
Gastroenterology in children, nutrition in children, liver regeneration, liver diseases in children

Areas of Research Interest
Special interest in the mechanisms that regulate liver regeneration

Board Certification
Pediatrics -- Certified
Pediatric Gastroenterology -- Certified

Medical Education
B.S.: University of Illinois, Champaign-Urbana, Illinois, 1987
Medical Degree: Washington University School of Medicine, St. Louis, Missouri, 1994
Ph.D.: Washington University School of Medicine, St. Louis, Missouri, 1994
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri, 1997
Fellowship: Pediatric Gastroenterology and Nutrition, Washington University School of Medicine, St Louis MO, 2000
Hospital Affiliations
St. Louis Children's Hospital

Honors and Awards
Listed in Best Doctors in America, 2007-2013 (Best Doctors, Inc.)
WUSM - The George F. Gill Prize in Pediatrics, 1994
WUSM - American Federation for Clinical Research, Medical Student Award, 1992

Selected or Recent Journal Articles
Huang J, Barr E, Rudnick DA. Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration. Hepatology. 2013 May;57(5):1742-51.

Gazit V, Huang J, Weymann A, Rudnick DA. Analysis of the role of hepatic PPARγ expression during mouse liver regeneration. Hepatology. 2012 Oct;56(4):1489-98.

Huang J, Glauber M, Qiu Z, Gazit V, Dietzen DJ, Rudnick DA. The influence of skeletal muscle on the regulation of liver:body mass and liver regeneration. Am J Pathol. 2012 Feb;180(2):575-82.

Rudnick DA, Davidson NO. Functional Relationships between Lipid Metabolism and Liver Regeneration. Int J Hepatol. 2012;2012:549241.

Gazit V, Weymann A, Hartman E, Finck BN, Hruz PW, Tzekov A, Rudnick DA. Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology. 2010 Dec;52(6):2109-17.

Ge J, Rudnick DA, He J, Crimmins DL, Ladenson JH, Bessler M, Mason PJ. Dyskerin ablation in mouse liver inhibits rRNA processing and cell division. Mol Cell Biol. 2010 Jan;30(2):413-22.

Qiu Z, Longshore SW, Warner BW, Rudnick DA. Murine functional liver mass is reduced following partial small bowel resection. J Gastrointest Surg. 2009 Dec;13(12):2176-82.

Weymann A, Hartman E, Gazit V, Wang C, Glauber M, Turmelle Y, Rudnick DA. p21 is required for dextrose-mediated inhibition of mouse liver regeneration. Hepatology. 2009 Jul;50(1):207-15.

Rudnick DA, Dietzen DJ, Turmelle YP, Shepherd R, Zhang S, Belle SH, Squires R; Pediatric Acute Liver Failure Study Group. Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure. Pediatr Transplant. 2009 Mar;13(2):223-30.

Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, Rudnick DA. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol. 2008 Jun;45(11):3125-32.

Turmelle YP, Shikapwashya O, Tu S, Hruz PW, Yan Q, Rudnick DA. Rosiglitazone inhibits mouse liver regeneration. FASEB J. 2006 Dec;20(14):2609-11. Epub 2006 Oct 31.

Rudnick DA, Shikapwashya O, Blomenkamp K, Teckman JH. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology. 2006 Oct;44(4):976-82.

Rudnick DA, Perlmutter DH. Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease. Hepatology. 2005 Sep;42(3):514-21. Review.

Shteyer E, Liao Y, Muglia LJ, Hruz PW, Rudnick DA. Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology. 2004 Dec;40(6):1322-32.

Liao Y, Shikapwashya ON, Shteyer E, Dieckgraefe BK, Hruz PW, Rudnick DA. Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice. J Biol Chem. 2004 Oct 8;279(41):43107-16. Epub 2004 Jul 20.

For more articles or abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. David A. Rubin.

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Copyright 2015 Washington University School of Medicine