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Neurology / Pediatric

Kwee Liu Lin Thio, MD

Current Position
Associate Professor, Neurology, Pediatrics and Neurobiology
Division of Pediatric Neurology
Director, Pediatric Epilepsy Center
Neurologist-in-Chief, St. Louis Children's Hospital

Specialty Areas
Pediatric Neurology
Cerebral Palsy
Pediatric Epilepsy

Patients Seen At
St Louis Children's Hospital - Pediatric Epilepsy Center
One Children's Place, Suite D
St Louis, MO  63110
Fax:   314-454-2623
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric neurology, epilepsy, seizures, cerebral palsy, autism, congenital neurological conditions, intensive neurology care for infants and children.

Board Certification
Neurology -- Board Qualified
Pediatrics -- Board Qualified

Medical Education
B.S.: Biochemistry, Brown University, Providence, Rhode Island, 1984
Medical Degree: Washington University School of Medicine, St Louis, Missouri, 1992
Ph.D.: Neuroscience, Washington University School of Medicine, St Louis, Missouri, 1992
Residency: Pediatrics, St Louis Children's Hospital at Washington University, St Louis, Missouri, 1994
Residency: Neurology, Barnes Hospital at Washington University, St Louis, Missouri, 1995
Residency: Pediatric Neurology, St Louis Children's Hospital at Washington University, St Louis, Missouri , 1997
Fellowship: Pediatric Epilepsy, St Louis Children's Hospital at Washington University, St Louis, Missouri, 1998
Fellowship: Pediatric Epilepsy, Children's Hospital at Harvard University, Boston, Massachusetts, 1999
Hospital Affiliations
St Louis Children's Hospital

Honor and Awards
Listed in Best Doctors in America, 2007-2013 (Best Doctors, Inc.)

Book Chapter
Merlie JP, Buonanno A, Carlin B, Covault J, Crowder CM, Dietz T, Frail D, Isenberg KI, Lawrence J, Mudd J, Sanes J, Shah V, Smith MM, Thio LL. Coordinate regulation of expression of synaptic proteins in skeletal muscle: Studies with acetylcholine receptor. Proteins of excitable membranes, ed. Hille B & Fambrough DM, pp. 77-97, Wiley-Interscience, NY, 1987

Journal Articles
Titus JB, Thio LL. The effects of antiepileptic drugs on classroom performance. Psychology in the Schools 2009, In press.

Zhang HX, Hyrc K, Thio LL. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. In Revision for Journal of Physiology, 2009

Thio LL, Rensing N, Hagely J, Maloney S, Wozniak D, Xiong C, Yamada KA. A ketogenic diet increases superoxide but does not impair rat behavior or LTP. In Revision for Epilepsia, 2009

Thio LL, Wong M, Yamada KA. Leptin: the ketogenic diet's link to the brain. Submitted, 2009

Xu L, Rensing N, Yang X-F, Zhang HX, Thio LL, Rothman SM, Weisenfeld AE, Wong M, Yamada KA. Leptin inhibits 4-aminopyridine and pentylenetetrazole induced seizures and AMPAR mediated synaptic transmission. Journal of Clinical Investigation 2008; 118: 272-280.

Erbayat-Altay E, Yamada KA, Wong M, Thio LL. Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice. Neuroscience Letters 2008; 433: 82-86.

Karkar KM, Thio LL, Yamada K. Effects of seven clinically important antiepileptic drugs on inhibitory glycine receptor currents in hippocampal neurons. Epilepsy Research 2004; 58:27-35

Thio LL, Yamada KA. Differential presynaptic modulation of excitatory and inhibitory autaptic currents in cultured hippocampal neurons. Brain Research 2004; 1012:22-28

Izumi Y, Ishikawa M, Benz AM, Izumi M, Zorumski CF, Thio LL. Acute vigabatrin retinotoxicity depends on light but not GABA. Epilepsia 2004; 45:1043-1048

Thio LL, Shanmugam A, Isenberg K, Yamada K. Benzodiazepines block a2-containing inhibitory glycine receptors in embryonic mouse hippocampal neurons. Journal of Neurophysiology 2003; 90:89-99

Xia S, Cai ZY, Thio LL, Kim-Han JS, Dugan LL, Covey DF, Rothman SM. The estrogen receptor is not essential for all estrogen neuroprotection: New evidence from a new analog. Neurobiol Dis 2002; Apr;9(3):282-93

Thio LL, Wong M, Yamada KA. Ketone bodies do not directly alter excitatory or inhibitory synaptic transmission. Neurology 2000; 54:325-331

Zorumski CF, Thio LL. Properties of vertebrate glutamate receptors: Calcium mobilization and desensitization. Progress in Neurobiology 1992; 39:295-336

Zorumski CF, Thio LL, Clark GD, Clifford DB. Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons. Neuron 1990; 5:61-66

Trussell LO, Thio LL, Zorumski CF, Fischbach GD. Rapid desensitization of glutamate receptors in vertebrate central neurons. Proceedings of the National Academy of Sciences of the USA 1988; 85:4562-4566

Bushman W, Yin S, Thio LL, Landy A. Determinants of directionality in lambda site-specific recombination. Cell 1984; 39:699-706

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Kwee Liu Lin Thio

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Copyright 2014 Washington University School of Medicine