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Neurology / Pediatric

Kwee Liu Lin Thio, MD

Current Position
Associate Professor, Neurology, Pediatrics and Neurobiology
Division of Pediatric Neurology
Director, Pediatric Epilepsy Center
Neurologist-in-Chief, St. Louis Children's Hospital


Specialty Areas
Pediatric Neurology
Cerebral Palsy
Pediatric Epilepsy
Electromyography

Patients Seen At
St Louis Children's Hospital - Pediatric Epilepsy Center
One Children's Place, Suite D
St Louis, MO  63110
314-454-6120
Fax:   314-454-2623
Email:   thio@kids.wustl.edu
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric neurology, epilepsy, seizures, cerebral palsy, autism, congenital neurological conditions, intensive neurology care for infants and children.

Board Certification
Neurology -- Board Qualified
Pediatrics -- Board Qualified

Medical Education
B.S.: Biochemistry, Brown University, Providence, Rhode Island, 1984
Medical Degree: Washington University School of Medicine, St Louis, Missouri, 1992
Ph.D.: Neuroscience, Washington University School of Medicine, St Louis, Missouri, 1992
Residency: Pediatrics, St Louis Children's Hospital at Washington University, St Louis, Missouri, 1994
Residency: Neurology, Barnes Hospital at Washington University, St Louis, Missouri, 1995
Residency: Pediatric Neurology, St Louis Children's Hospital at Washington University, St Louis, Missouri , 1997
Fellowship: Pediatric Epilepsy, St Louis Children's Hospital at Washington University, St Louis, Missouri, 1998
Fellowship: Pediatric Epilepsy, Children's Hospital at Harvard University, Boston, Massachusetts, 1999
Hospital Affiliations
St Louis Children's Hospital

Honor and Awards
Listed in Best Doctors in America, 2007-2013 (Best Doctors, Inc.)

Selected or Recent Journal Articles
He Y, Brunstrom-Hernandez JE, Thio LL, Lackey S, Gaebler-Spira D, Kuroda MM, Stashinko E, Hoon AH Jr, Vargus-Adams J, Stevenson RD, Lowenhaupt S, McLaughlin JF, Christensen A, Dosa NP, Butler M, Schwabe A, Lopez C, Roge D, Kennedy D, Tilton A, Krach LE, Lewandowski A, Dai H, Gaedigk A, Leeder JS, Jusko WJ. Population Pharmacokinetics of Oral Baclofen in Pediatric Patients with Cerebral Palsy. J Pediatr. 2014 May;164(5):1181-1188.e8.

Paciorkowski AR, Weisenberg J, Kelley JB, Spencer A, Tuttle E, Ghoneim D, Thio LL, Christian SL, Dobyns WB, Paschal BM. Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation. Eur J Hum Genet. 2014 May;22(5):587-93.

Vining EP, Thio LL. Absence in childhood absence epilepsy: the horse is out of the barn. Neurology. 2013 Oct 29;81(18):1564-5.

Mitchell TJ, Neil JJ, Zempel JM, Thio LL, Inder TE, Bretthorst GL. Automating the analysis of EEG recordings from prematurely-born infants: a Bayesian approach. Clin Neurophysiol. 2013 Mar;124(3):452-61.

Hucthagowder V, Liu TC, Paciorkowski AR, Thio LL, Keller MS, Anderson CD, Herman T, Dehner LP, Grange DK, Kulkarni S. Chromosome 2p15p16.1 microdeletion syndrome: 2.5 Mb deletion in a patient with renal anomalies, intractable seizures and a choledochal cyst. Eur J Med Genet. 2012 Aug-Sep;55(8-9):485-9.

Thio LL. Hypothalamic hormones and metabolism. Epilepsy Res. 2012 Jul;100(3):245-51.

Paciorkowski AR, Thio LL, Dobyns WB. Genetic and biologic classification of infantile spasms. Pediatr Neurol. 2011 Dec;45(6):355-67.

Paciorkowski AR, Thio LL, Rosenfeld JA, Gajecka M, Gurnett CA, Kulkarni S, Chung WK, Marsh ED, Gentile M, Reggin JD, Wheless JW, Balasubramanian S, Kumar R, Christian SL, Marini C, Guerrini R, Maltsev N, Shaffer LG, Dobyns WB. Copy number variants and infantile spasms: evidence for abnormalities in ventral forebrain development and pathways of synaptic function. Eur J Hum Genet. 2011 Dec;19(12):1238-45.

McDaniel SS, Rensing NR, Thio LL, Yamada KA, Wong M. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia. 2011 Mar;52(3):e7-11.

Thio LL, Rensing N, Maloney S, Wozniak DF, Xiong C, Yamada KA. A ketogenic diet does not impair rat behavior or long-term potentiation. Epilepsia. 2010 Aug;51(8):1619-23.

Zhang HX, Lyons-Warren A, Thio LL. The glycine transport inhibitor sarcosine is an inhibitory glycine receptor agonist. Neuropharmacology. 2009 Oct-Nov;57(5-6):551-5.

Zhang HX, Hyrc K, Thio LL. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. J Physiol. 2009 Jul 1;587(Pt 13):3207-20.

Erbayat-Altay E, Yamada KA, Wong M, Thio LL. Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice. Neurosci Lett. 2008 Mar 12;433(2):82-6.

Xu L, Rensing N, Yang XF, Zhang HX, Thio LL, Rothman SM, Weisenfeld AE, Wong M, Yamada KA. Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J Clin Invest. 2008 Jan;118(1):272-80.

Zhang HX, Thio LL. Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons. J Neurophysiol. 2007 Dec;98(6):3666-76. Epub 2007 Oct 3.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Kwee Liu Lin Thio.

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Copyright 2014 Washington University School of Medicine