James E. Galvin, MD, MPH
Current Position
Associate Professor, Neurology
Associate Professor, Psychiatry and Neurobiology
Division of Adult Neurology
Director, Memory Diagnostic Center
Specialty Areas
Neurology - Adult
Parkinson's Disease
Dementia
Alzheimer's Disease
Mailing Address
|
Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis,
MO
63110
|
Areas of Clinical Interest
Alzheimer's disease, neurodegenerative disease, neurodegenerative disorders, dementia, Parkinson's disease, memory loss, Lewy body dementia, cognitive function, geriatric neurology
Board Certification
Neurology
--
Board Qualified
Medical Education
B.A.: Biology, New York University, New York, New York
, 1986
M.Sc.: Nutrition/Biochemistry, Rutgers University, New Brunswick, New Jersey
, 1991
Medical Degree: UMDNJ-New Jersey Medical School, Neward, New Jersey
, 1992
Residency: Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania
, 1993
Chief Residency: Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania
, 1996
Fellowship: Neurologic Rehabilitation, University of Pennsylvania, Philadelphia, PA
, 1997
Research Fellowship: Neurodegenerative Disease, University of Pennsylvania, Philadelphia, PA
, 2000
Hospital Affiliations
Barnes-Jewish Hospital
Major or Recent Publications/Awards
Editorial Responsibilities
Reviewer
Alzheimer’s Disease and Associated Disorders
American Journal of Pathology
Annals of Neurology
Archives of Neurology
Experimental Neurology
Journal of Alzheimer’s Disease and Other Dementias
Movement Disorders
Neurobiology of Aging
Neurobiology of Disease
Neurology
Neuroscience Letters
Proceedings of the National Academy of Science, USA
Honors and Awards
Research Award in Geriatric Neurology, American Academy of Neurology, 2006
Alene and Meyer Kopolow Award for Excellence in Geriatric Psychiatry and Neurology, Washington University, 2002
Robert J. Schwartzman Faculty Teaching Award 1999-2000
University Resident Teaching Award 1995-1996
Invited Papers and Book Chapters
Galvin JE. Parkinson’s Disease and Dementia with Lewy Bodies. In: HANDBOOK OF DEMENTING ILLNESSES, 2ND EDITION, Morris JC, Galvin JE, Holtzman DM (Eds). Marcel-Dekker, New York, NY, In Press 2006
Galvin JE. Predictors of Preclinical Alzheimer’s Disease. In: RESEARCH AND PRACTIVE OF ALZHEIMER’S DISEASE, Vol 6. Vellas B, Winblad B, Grundman M, Fitten LJ, Feldman H, Giacobini E, Kurz A. (Eds). Springer Publishing, New York, NY In Press 2006
Galvin JE, Palmer JL, Morris JC. Mild cognitive impairment represents early Alzheimer’s disease. In: RESEARCH AND PRACTIVE OF ALZHEIMER’S DISEASE, Vol 6. Vellas B, Winblad B, Grundman M, Fitten LJ, Feldman H, Giacobini E, Kurz A. (Eds). pp 38-42, Springer Publishing, New York, NY 2002
Giasson BI, Galvin JE, Lee VM-Y, Trojanowski JQ. The Cellular and Molecular Pathology of Parkinson's Disease. Neurodegenerative Dementias: Clinical Features and Pathologic Mechanisms. Clark CM, Trojanowski JQ (Eds.) pp 219-228, McGraw-Hill, New York, NY, 2000
Galvin JE, Lee VM-Y, Schmidt ML, Tu PH, Iwatsubo T, Trojanowski JQ. Pathobiology of the Lewy Body: Studies with Purified Lewy Bodies, Monoclonal Antibodies and LB-like Inclusions in Transgenic Animal Models. Advances in Neurology. Vol 80. Stern G (Ed.), pp. 313-324 Lippincott-Williams-Wilkins, New York, NY 1999
Trojanowski JQ, Galvin JE, Schmidt ML, Tu PH, Iwatsubo T, Lee VM-Y. Mechanisms of Neuron Death in Neurodegenerative Diseases of the Elderly: The Role of the Lewy Body. Handbook of the Aging Brain. Wang E, Snyder SD (Eds.) pp. 143-152, Academic Press, Orlando, FL 1998
Selected Journal Articles
Seugnet L, Galvin JE, Suzuki Y, Vine L, Shaw PJ. Persistent short-term memory defects following sleep deprivation in a Drosophila model of Parkinson's disease. Sleep, In Press 2009.
Johnson DK, Storandt M, Morris JC, Galvin JE. Longitudinal study of the transition from healthy aging to Alzheimer disease. Arch Neurol In Press, 2009.
Galvin JE. When a tremor is not just a tremor: Cognitive and functional decline in Essential Tremor, a more complex disorder that we thought. J Am Med Dir Assoc In Press 2009.
Norton JB, Cairns N, Galvin JE, Goate A. Presenilin 1 g217r mutation linked to alzheimer¹s disease with cotton wool plaques. Neurology In Press 2009
Galvin JE, Meuser TM, Boise L, Connell CM. Determinants of physician referral for patient recruitment to Alzheimer disease clinical trials. Alz Dis Assoc Disord, In Press, 2009
Galvin JE, Meuser TM, Coats MA, Bakal DA, Morris JC. The portable CDR: Translating the Clinical Dementia Rating interview into a PDA format. Alz Dis Assoc Disord 23:44-49, 2009
Sevigny JJ, Ryan JM, van Dyck CH, Peng Y, Lines CR, Nessly ML; MK-677 Protocol 30 Study Group. Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial. Neurology. 71:1702-1708,2008.
Johnson DK, Storandt M, Morris JC, Galvin JE. Cognitive profiles in dementia: Alzheimer disease versus nondemented aging. Neurology 71:1783-1789,2008.
Galvin JE, Fu Q, Nguyen JT, Glasheen C, Scharff DP. Psychosocial Determinants of Intention to Screen for Alzheimer Disease. Alzheimer Dement 4:353-360;2008
Fleisher AS, Raman R, Siemers ER, Clark CM, Farlow MR, Galvin JE, Peskind ER, Quinn JF, Shezai AD, Aisen PS, Thal LJ. Phase II trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer's Disease. Arch Neurol, 65:1031-1038,2008
Galvin JE, Cornblatt B, Newhouse P, Ancoli-Israel, Wesnes K, Williamson D, Zhu Y, Sorra K, Amatniek J. Attention Deficits in Alzheimer's Disease: Two Head-to-Head Studies of Galantamine and Donepezil. Alz Dis Assoc Disord, 22:30-38, 2008.
Pandey N, Strider J, Nolan WC, Yan SX, Galvin JE. Curcumin inhibits aggregation of -synuclein. Acta Neuropathol. 115:479-489, 2008
Burke WJ, Kumar VB, Pandey N, Franko MW, O'Dell M, Chung HD, Galvin JE. DOPAL, the MAO Metabolite of Dopamine is Responsible for Dopamine Neuron Loss and Triggers -Synuclein Aggregation in vitro. Acta Neuropathologica, 115:193-203,2008
Tarawneh R, Galvin JE. Distinguishing Lewy Body Dementias from Alzheimer disease. Expert Rev Neurotherap, 7:1499-1516, 2007
Galvin JE. Pass the grain; spare the brain. Neurology, 69:1072-1073, 2007.
Galvin JE, Malcom H, Johnson DK, Morris JC. Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease. Neurology 68:1895-1901, 2007.
Galvin JE. Alzheimer Disease: Understanding the Challenges, Improving the Outcome. App Neurol, Suppl (Feb):3-13; 2007.
Galvin JE, Roe CM, Coats MA, Morris JC. Patients rating of cognitive ability: Using the AD8, a brief informant interview as a self rating tool to detect dementia. Arch Neurol 64:725-730, 2007
Galvin JE, Roe CM, Morris JC. Evaluation of cognitive impairment in the older adult: combining brief informant and performance measures. Arch Neurol 64:718-724, 2007
Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM-Y, Leverenz JB, Masliah E, McKeith IG, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK. DLB and PDD Working Group Symposium: Boundary Issues and Future Priorities. Neurology 68:812-819, 2007.
Galvin JE, Scharff DP, Glasheen C, Fu Q. Development of a Population-based Questionnaire to Explore Psychosocial Determinants of Screening for Memory Loss and Alzheimer Disease. Alzheimer Dis Assoc Disord. 2006; July/September; 20(3):182-191.
PMID: 16917189 [PubMed - as supplied by publisher]
Galvin JE. Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. Acta Neuropathol (Berl). 2006 Aug;112(2):115-126. Epub 2006 Jun 22.
PMID: 16791599 [PubMed - as supplied by publisher]
Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, Tariot P, Zoulnouni P, Galvin JE, Holtzman DM, Knopman DS, Satterwhite J, Gonzales C, Dean RA, May PC. Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.Neurology. 2006 Feb 28;66(4):602-4.
PMID: 16505324 [PubMed - indexed for MEDLINE]
Pandey N, Schmidt RE, Galvin JE. The alpha-synuclein mutation E46K promotes aggregation in cultured cells.
Exp Neurol. 2006 Feb;197(2):515-20. Epub 2005 Dec 1.
PMID: 16325180 [PubMed - indexed for MEDLINE]
Galvin JE. Alzheimer’s Disease: Diagnosis and Treatment Across the Spectrum. App Neurol 2005; Suppl 1 (Nov):1-16
Johnson DK, Morris JC, Galvin JE. Verbal and visuospatial deficits in dementia with Lewy bodies. Neurology 2005; 65:1232-1238
Galvin JE, Ginsberg SD. Expression Profiling in the Aging Brain: A Perspective. Aging Res Rev 2005; 4:529-547
Csernansky JG, Wang L, Miller JP, Galvin JE, Morris JC. Neuromorphometric Predictors of Response to Donepezil in Dementia of the Alzheimer Type. Arch Neurol 2005; 62:1718-1722
Galvin JE, Roe C, Coats M, Powlishta KK, Muich SJ, Grant E, Storandt M, Miller JP, Morris JC. The AD8: A Brief Informant Interview to Detect Dementia. Neurology 2005; 65:559-564
Galvin JE, Powlishta KK, Wilkins K, McKeel Jr DW, Storandt M, Grant E, Morris JC. Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study. Arch Neurol 2005; 62:758-765
Burns JM, Galvin JE, Roe CM, Morris JC, McKeel DW Jr. The Pathology of the Substantia Nigra in Alzheimer’s Disease with Extrapyramidal Signs. Neurology, 2005; 64:1397-1403
Galvin JE, Ginsberg SD. Expression Profiling and Pharmacotherapeutic Development in the Central Nervous System. Alz Dis Assoc Disor 2004; 18:264-269
Galvin JE, Lee SL, Perry A, Havioglu N, McKeel DW, Morris JC. Clinicopathologic correlates in Familial Dementia with Lewy Bodies. Dementia 2004; 2:14-17
Galvin JE. Gene Expression Profiling the Neuropathology of Neurodegenerative Disease Neurochem Res 2004; 29:1041-1051
Galvin JE. Detection of aggregates and protein inclusions by staining of tissues. Method Mol Med 2003; 232:149-164
Galvin JE. Dementia with Lewy bodies. Arch Neurol 2003; 60:1332-1335
Galvin JE, Lee SL, Perry A, Havioglu N, McKeel DW, Morris JC. Familial Dementia with Lewy Bodies: Clinicopathological Analysis of Two Kindreds. Neurology 2002; 59:1079-1082
Galvin JE, Schuck TM, Lee VM-Y, Trojanowski JQ. Differential expression and distribution of Alpha-, Beta- and Gamma-synuclein in the developing human substantia nigra. Exp Neurol 2001; Apr;168(2):347-55
Galvin JE, Lee VM-Y, Trojanowski JQ. Syunucleinopathies: Clinical and pathologic implications. Arch Neurol 2001; Feb;58(2):186-90, Review
Galvin JE, Giasson BI, Lee VM-Y, Trojanowski JQ. Neurodegeneration with brain iron accumulation, type I (NBIA 1) is characterized by a-, b- and g-synuclein neuropathology. Am J Pathol 2000; 157:361-368
Hurtig HI, Trojanowski JQ, Galvin JE, Ewbank D, Schmidt ML, Lee VM-Y, Clark CM, Glosser G, Stern MB, Gollomp SM, Arnold SE. Alpha-synuclein cortical lewy bodies are markers for dementia. Neurology 2000; 54:1916-1921
For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. James E. Galvin