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Surgery / General Surgery - Hepatic, Biliary, Pancreatic, GI

David C. Linehan, MD

Current Position
Chief, Section of Hepatobiliary-Pancreatic and Gastrointestinal Surgery
Professor, Surgery
Division of General Surgery
Hepatobiliary-Pancreatic and Gastrointestinal Surgery Section

Specialty Areas
Hepatobiliary Pancreatic (HPB) Surgery
Liver Surgery
Hepatobiliary Pancreatic Cancer
General Surgery
Gallbladder Surgery
Biliary Surgery
Pancreatic Surgery
Hepatobiliary Surgery
Pancreatic Cancer
Gastrointestinal Oncology
Gastrointestinal Surgery

Patients Seen At
Center for Advanced Medicine
GI Center
4921 Parkview Place, C, 8
St. Louis, MO  63110
Fax:   314-222-6255
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Siteman Cancer Center
Medical Building Two
Barnes-Jewish West County Hospital
10 Barnes West Drive, First Floor
Creve Coeur, MO  63141
Fax:   314-367-1943
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Mailing Address
Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8109
St. Louis, MO  63110

Areas of Clinical Interest
Dr. Linehan specializes in treating soft tissue sarcoma; and surgical treatment of benign and malignant diseases of the bile duct, gallbladder, gastrointestinal tract, liver and pancreas.

Areas of Research Interest
Dr. Linehan has recent or ongoing studies of aspects of chemoradiation following pancreaticoduodenectomy for adenocarcinoma of the pancreas, proteomic profiling in patients with resectable adenocarcinoma of the pancreas, proteomic approach to markers for regulatory T cells, and biomarkers of prognosis in pancreas cancer.

Board Certification
Surgery -- Certified

Medical Education
Medical School: University of Massachusetts, Worcester, MA, 1990
Fellowship: Laboratory Biologic Cancer Therapy Brigham & Women's Hosp, Harvard Medical School, Boston, MA, 1995
Residency: Deaconnes-Harvard Surgical Service, Harvard Medical School, Boston, MA, 1997
Fellowship: Kristin Ann Carr Fellow in Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, 1999
Hospital Affiliations
Barnes-Jewish Hospital

Honors and Awards
Listed in Best Doctors in America, 2005-2013 (Best Doctors, Inc.)

Society of Surgical Oncology, Executive Council Chairman, 2008-2009

St. Louis Surgical Society Executive Council, 2009

National Cancer Institute Study Section

Alvin J. Siteman Cancer Center, Protocol Review Monitoring Committee 2001-2009

Cancer Treatment Research Foundation (CTRF) Superhero Cancer Research Award, Chicago, 2006

Selected or Recent Journal Articles
Hashim YM, Trinkaus KM, Linehan DC, Strasberg SS, Fields RC, Cao D, Hawkins WG. Regional Lymphadenectomy Is Indicated in the Surgical Treatment of Pancreatic Neuroendocrine Tumors (PNETs). Ann Surg. 2014 Feb.

Jin LX, Fields RC, Hawkins WG, Linehan DC, Strasberg SM. A New Operative Approach for Type I Choledochal Cysts. J Gastrointest Surg. 2013 Nov 13.

Zhong H, Sanchez C, Spitrzer D, Plambeck-Suess S, Gibbs J, Hawkins WG, Denardo D, Gao F, Pufahl RA, Lockhart AC, Xu M, Linehan D, Weber J, Wang-Gillam A. Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models. PLoS One. 2013 Oct 9.

Capietto AH, Kim S, Sanford DE, Linehan DC, Hikida M, Kumosaki T, Novack DV, Faccio R. Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer. J Exp Med. 2013 Oct 21.

Sanford DE, Porembka MR, Panni RZ, Mitchem JB, Belt BA, Plambeck-Suess SM, Lin G, Denardo DG, Fields RC, Hawkins WG, Strasberg SM, Lockhart AC, Wang-Gillam A, Goedegebuure SP, Linehan DC. A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma. J Cancer Ther. 2013 May.

Panni RZ, Linehan DC, DeNardo DG. Targeting tumor-infiltrating macrophages to combat cancer. Immunotherapy. 2013 Oct.

Sanford DE, Belt BA, Panni RZ, Mayer A, Deshpande AD, Carpenter D, Mitchem JB, Plambeck-Suess SM, Worley LA, Goetz BD, Wang-Gillam A, Eberlein TJ, Denardo DG, Goedegebuure SP, Linehan DC. Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis. Clin Cancer Res. 2013 Jul 1.

Strasberg SM, Gao F, Sanford D, Linehan DC, Hawkins WG, Fields R, Carpenter DH, Brunt EM, Phillips C. Jaundice: an important, poorly recognized risk factor for diminished survival in patients with adenocarcinoma of the head of the pancreas. HPB (Oxford). 2014 Feb.

Idrees K, Edler JR, Linehan DC, Strasberg SM, Jacques D, Hamilton NA, Fields RC, Lambert D, Kymes S, Hawkins WG. Cost benefit analysis of mesh reinforcement of stapled left pancreatectomy. HPB (Oxford). 2013 Feb 20.

Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res. 2013 Feb 1.

Fowler KJ, Linehan DC, Menias CO. Colorectal liver metastases: state of the art imaging. Ann Surg Oncol. 2013 Apr.

Peddi PF, Lubner S, McWilliams R, Tan BR, Picus J, Sorscher SM, Suresh R, Lockhart AC, Wang J, Menias C, Gao F, Linehan D, Wang-Gillam A. Multi-institutional experience with FOLFIRINOX in pancreatic adenocarcinoma. JOP. 2012 Sep 10.

Gnerlich JL, Luka SR, Deshpande AD, Dubray BJ, Weir JS, Carpenter DH, Brunt EM, Strasberg SM, Hawkins WG, Linehan DC. Microscopic margins and patterns of treatment failure in resected pancreatic adenocarcinoma. Arch Surg. 2012 Aug.

Hamilton NA, Porembka MR, Johnston FM, Gao F, Strasberg SM, Linehan DC, Hawkins WG. Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial. Ann Surg. 2012 Jun.

Hamilton NA, Liu TC, Cavatiao A, Mawad K, Chen L, Strasberg SS, Linehan DC, Cao D, Hawkins WG. Ki-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasms. Surgery. 2012 Jul.

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