Internal Medicine / Gastroenterology

The Washington University physicians in the Department of Internal Medicine encompass 14 specialty clinical divisions.

Over 270 physicians in the department of medicine treat patients with a wide range of diseases, disorders and conditions.

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Nicholas O. Davidson, MD

Specialty Areas
Gastroenterology
Gastrointestinal Oncology
Gastrointestinal Disease

Areas of Clinical Interest
Familial gastrointestinal cancer syndromes, hereditary polyposis syndromes, colorectal cancer genetics

Major or Recent Publications/Awards

Honors and Awards

Association of Amercian Physicians, 2000

Gastrointestinal Research Group-American Gastroenterological Association Young Physician-Scientist Award, 1993

D. Sc Degree, University of London, 2002

Original Scientific Publications

Davidson NO. Genetic Testing in Colorectal Cancer: Who, When, How and Why. Keio J Med 2007; 56(1): 14-20

Xie Y, Davidson NO. Low HDL Cholesterol Levels. N Engl J Med 2006; 26;354(4): 417-419

Chirieac DV, Davidson NO, Sparks CE, Sparks JD. PI 3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-1- mice. Am J Physiol Gastrointest Liver Physiol 2006; In press

Elwing JE, Gao F, Davidson NO, Early DS. Type 2 Diabetes Mellitus: The impact on colorectal adenomas in women. Am J Gastroenterol 2006; In press

Tang Y, Swietlicki EA, Jiang S, Buhman KK, Davidson NO, Burkly LC, Levin MS, Rubin DC. Increased Apoptosis and Accelerated Epithelial Migration Following Inhibition of Hedgehog Signaling in Adaptive Small Bowel Post-Resection. Am J Physiol Gastrointest Liver Physiol 2006; 290:1280-1288

Cho S-J, Dreschler H, Burke RC, Arens MQ, Powderly W, Davidson NO. APOBEC3F and APOBEC3G mRNA levels do not correlate with human immunodeficiency virus type 1 plasma viremia or CD4+ T-cell counts. J Virol, 2006; 80:2069-2072

Xie Y, Newberry EP, Young SG, Robine S, Hamilton RL, Wong JS, Luo J, Davidson NO. Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. J Biol Chem, 2006; 281:4075-4086

Stone CD, Klein S, McDoniel K, Davidson NO, Prakash C, Strasberg SM. Celiac disease unmasked after pancreaticoduodenectomy. J Paren Enteral Nutr 2005; 29:270-271

Sha J, McCullough B, Hart E, Nassir F, Davidson NO, Hoover-Plow J. Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen. J Thromb Haemost 2005; 3:2281-2289

Blanc V, Henderson JO, Newberry EP, Kennedy S, Luo J, Davidson NO. Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality. Mol Cell Biol 2005; 26(16):7260-7269

Davidson NO. Grant writing and academic survival: What the fellow needs to know. Gastrointest. Endosc 2005; 61(6):726-727

Lin X, Yue P, Xie Y, Davidson, NO, Sakata N, Ostlund RE, Chen Z, Schonfeld G. Reduced intestinal fat absorptive capacity but enhanced susceptibility to diet-induced fatty liver in mice heterozygous for ApoB38.9 truncations. Am J Physiol 2005; (GI/Liver) 289:G146-G152

Drover VA, Ajmal M, Nassir F, Davidson NO, Tso P, Abumrad NA. CD36 deficiency reduces both intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest 2005; 115:1290-1297

Buhman KK, Wang LC, Tang Y, Swietlicki EA, Kennedy S, Xie Y, Liu ZY, Burkly LC, Levin MS, Rubin DC, Davidson NO. Inhibition of hedgehog signaling protects adult mice from diet-induced weight gain. J Nutr 2004; 134:2979-2984

Anant S, Murmu N, Houchen CW, Mukhopadhyay D, Riehl TE, Young SG, Morrison AR, Stenson WF, Davidson NO. Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. Gastroenterology 2004; 127:1139-49

Bishop KN, Holmes RK, Sheehy AM, Davidson NO, Cho SJ, Malim MH. Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Curr Biol 2004; 10:1392-1396

Nassir F, Xie Y, Patterson BW, Luo J, Davidson NO. Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor. J Lipid Res 2004; 45:1649-1659

Banerjee B, Henderson JO, Chaney TC, and Davidson NO. Detection of murine intestinal adenomas using targeted molecular autofluorescence. Dig Dis Sci 2004; 49:54-59

Nassir F, Xie Y and Davidson NO. Apolipoprotein[a] secretion from hepatoma cells is regulated in a size-dependent manner by alterations in disulfide bond formation. J Lipid Res 2003; 44:816-27

Blanc V, Davidson NO. C-to-U RNA Editing: Mechanisms Leading to Genetic Diversity. J Biol Chem 2003; 278:1395-1398

Anant S and Davidson NO. Hydrolytic nucleoside and nucleotide deamination, and genetic instability: a possible link between RNA-editing enzymes and cancer? Trends Mol Med 2003; 9:147-52

Anant S and Davidson NO. Identification and regulation of protein components of the Apolipoprotein B mRNA editing enzyme. A complex event. Trends In Cardiovasc. Med 2002; 12:311-317

Thompson FJ, Britton C, Wheatley I, Maitland K, Walker G, Anant S, Davidson NO and Devaney E. Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans. Biochem J 2002; 365:99-107

Anant S, Mukhopadhyay D, Hirano K, Brasitus TA, Davidson NO. Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs. Biochim Biophys Acta 2002; 1575:54-62

Wang L-C, Nassir F, Liu Z-Y, Ling L, Kuo F, Crowell T, Olson D, Davidson NO, Burkly LC. Disruption of hedgehog signalling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism. Gastroenterology 2002; 122:469-482

Davidson NO. The challenge of target sequence specificity in C-->U RNA editing. J Clin Invest 2002; 109(3):291-4

Mukhopadhyay D, Anant S, Lee RM, Kennedy S, Viskochil D, Davidson NO. C to U RNA editing of neurofibromatosis 1 mRNA occurs in tumors that express the type II transcript and that also express apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing enzyme. Am J Hum Genet 2002; 70:38-50

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Nicholas O. Davidson

Nicholas O. Davidson, MD