Obstetrics and Gynecology / Reproductive Endocrinology and Infertility

The specialists in the Division of Reproductive and Endocrinology provide a full line of services for women from menstruation through menopause.

Each year, more than 2,000 couples are evaluated and treated for infertility at The Infertility and Reproductive Medicine Center at Barnes-Jewish Hospital. We offer a full line of leading-edge medical and surgical services to both diagnose and treat the causes of infertility. The latest fertility drug therapies (both oral and injectable medications) are used in ovulation induction and with intrauterine insemination.

Washington University reproductive endocrinologists are specialists in the use of sonohysterography, hysteroscopy and laparoscopy to diagnose and treat infertility.

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Kelle H. Moley, MD

Specialty Areas
Reproductive Endocrinology and Infertility

Areas of Clinical Interest
Reproductive endocrinology, polycystic ovary syndrome, gynecology, obstetrics, hyperglycemia, hyperinsulinemia, ob/gyn, hirsutism, glucose intolerance, infertility, women's health.

Division of Reproductive Endocrinology and Infertility web site

Major or Recent Publications/Awards

Honors and Awards

James P. Crane Endowed Chair in Obstetrics and Gynecology, 2009
President's Achievement Award, 2007
Listed in America's Top Doctors, Castle & Connolly Ltd., 2007
Burroughs Welcome Development Award, 1998-2003
Reproductive Sciences Development Program Award, 1993-1998
Alpha Omega, 1987
Phi Beta Kappa, 1983

Journal Articles/Book Chapters

Wang Q, Ratchford AM, Chi MM, Schoeller E, Frolova A, Schedl T, Moley KH.
Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Mol Endocrinol. 2009 In press.

Doblado MA, Moley KH. Facilitative glucose transporter 9 (GLUT9), a unique hexose and urate transporter. Am J Physiol Endocrinol Metab. 2009 In press.

Kim ST, Moley KH. Regulation of Facilitative Glucose Transporters and AKT/MAPK/PRKAA Signaling via Estradiol and Progesterone in the Mouse Uterine Epithelium. Biol Reprod. 2009, 81:188-98.

Flessner LB, Moley KH. Similar [DE]XXXL[LI] motifs differentially target GLUT8 and GLUT12 in Chinese hamster ovary cells. Traffic, 2009,10:324-33.

Frolova A, Flessner L, Chi M, Kim ST, Foyouzi-Yousefi N, Moley KH. Facilitative glucose transporter type 1 is differentially regulated by progesterone and estrogen in murine and human endometrial stromal cells. Endocrinology. 2009, 150:1512-20.

Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P, Shaw-Hawkins S, Dobson RJ, Wallace C, Newhouse SJ, Brown M, Connell JM, Dominiczak A, Farrall M, Lathrop GM, Samani NJ, Kumari M, Marmot M, Brunner E, Chambers J, Elliott P, Kooner J, Laan M, Org E, Veldre G, Viigimaa M, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Moley KH, Cheeseman C. SLC2A9 is a high-capacity urate transporter in humans. PLoS Med. 2008, 5:e197.

Pinto AB, Carayannopoulos MO, Hoehn A, Dowd L, Moley KH. Glucose transporter 8 expression and translocation are critical for murine blastocyst survival. Biol Reprod 2002; Jun;66(6):1729-33

Pinto AB, Schlein AL, Moley KH. Preimplantation exposure to high insulin-like growth factor I concentrations results in increased resorption rates in vivo. Hum Reprod 2002; Feb;17(2):457-62

Moley KH. Hypogycemia and apoptosis - mechanisms for congenital malformation in embryos of diabetic women. Trends in Endocrinology and Metabolism 2001; 12:43-85

Chi MM-Y, Pingsterhaus JM, Carayannopoulos MO, Moley KH. Decreased glucose transport triggers Bax-dependent apoptosis in the murine blastocyst. Journal of Biological Chemistry 2000; 275:40252-40257

Carayannopoulos MO, Chi MM-Y, Cui Y, Pingsterhaus JM, Moley KH. Glut8, a novel glucose transporter responsible for insulin-stimulated glucose uptake in the mammalian preimplantation embryo. Proc Natl Acad Sci 2000; 97:7313-7318

Moley KH, Muckler MM. Glucose transport and apoptosis. Apoptosis 2000; 5:99-105

Chi MM-Y, Schlein AL, Moley KH. High IGF and insulin concentrations trigge apoptosis in the mouse blstocyst via down-regulation of the IGF-1 receptor. Endocrinology 2000; 141:4784-4792

Moley KH. Diabetes and preimplantation events of embryogenesis. In Seminars in Reproductive Endocrinology, ed E. Albert Reece, 1999, 19:137-151

Moley KH, Chi MM-Y, Knudson CM, Korsmeyer SJ, Mueckler MM. Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. Nature Med 1998; 4:1421-1424

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Kelle H. Moley

Kelle H. Moley, MD