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Pediatrics

Scott Saunders, MD, PhD

Current Position
Associate Professor, Pediatrics and Developmental Biology
Division of Newborn Medicine
Medical Director, St. Louis Children’s Hospital Critical Care Transport Team


Specialty Areas
Newborn Medicine - Neonatology
Neonatal/Perinatal Medicine
Transport Medicine

Patients Seen At
St Louis Children's Hospital
One Children's Place, Neonatal Intensive Care Unit (NICU), 5th Floor
St. Louis, MO  63110
314-454-6148
Fax:   314-454-4633
View Driving Directions

Mailing Address
Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8116
St. Louis, MO  63110

Areas of Clinical Interest
Congenital birth defects, genetic disorders, transport medicine

Board Certification
Neonatal-Perinatal Medicine -- Certified
Pediatrics -- Certified

Medical Education
B.S.: University of Minnesota, Minneapolis, MN, 1983
PhD: Stanford Univeristy School of Medicine, Stanford, CA, 1990
Medical School: Stanford University School of Medicine, Stanford, CA, 1990
Residency: Pediatric Medicine, Children's Hospital, Boston, MA, 1993
Research Fellowship: Brain and Cognitive Sciences, Massachusetts Institute of Technololgy, Cambridge, MA, 1995
Clinical Fellowship: Newborn Medicine, Joint Program in Neonatology, Harvard Medical School, Boston, MA, 1996
Research Fellowship: Developmental and Cell Biology, University of California at Irvine, Irvine, CA, 1997
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital

Honors and Awards
Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians, 1994
Spoehrer Scholar in Pediatrics, 1999
Society for Pediatric Research, Member, 2001
Executive Committee of the Faculty Council, WUSM, 2011 – Pres
Faculty Senate Council, Washington University, 2011 - Pres

Selected or Recent Journal Articles
Ellies, D. L., Economou, A., Viviano, B., Rey, J. P., Paine-Saunders, S., Krumlauf, R., Saunders, S. Wise Regulates Bone Deposition through Genetic Interactions with Lrp5. PLoS One 2014 May 1;9 (5), e96257.

Stankiewicz, P., Kulkarni, S., Dharmadhikari, A. V., Sampath, S., Bhatt, S. S., Shaikh, T. H., Xia, Z., Pursley, A. N., Cooper, M. L., Shinawi, M., Paciorkowski, A. R., Grange, D. K., Noetzel, M. J., Saunders, S., Simons, P., Summar, M., Lee, B., Scaglia, F., Fellmann, F., Martinet, D., Beckmann, J. S., Asamoah, A., Platky, K., Sparks, S., Martin, A. S., Madan-Khetarpal, S., Hoover, J., Medne, L., Bonnemann, C. G., Moeschler, J. B., Vallee, S. E., Parikh, S., Irwin, P., Dalzell, V. P., Smith, W. E., Banks, V. C., Flannery, D. B., Lovell, C. M., Bellus, G. A., Golden-Grant, K., Gorski, J. L., Kussmann, J. L., McGregor, T. L., Hamid, R., Pfotenhauer, J., Ballif, B. C., Shaw, C. A., Kang, S. H., Bacino, C. A., Patel, A., Rosenfeld, J. A., Cheung, S. W., Shaffer, L. G. Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats. Hum Mutat, 2012 Jan;33 (1), 165-79.

Thach, B. T., Kenney-Hunt, J. P., Simon, T. C., Stratman, J. L., Thach, S. B., Harris, K. A., Saunders, S., Cheverud, J. M. (2009). Sex-specific quantitative trait loci linked to autoresuscitation failure in SWR/J mice. Heredity (Edinb), 2009 Dec;103 (6), 469-75.

Ng, A., Wong, M., Viviano, B., Erlich, J. M., Alba, G., Pflederer, C., Jay, P. Y., Saunders, S. Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol, 2009 Nov 1;335 (1), 208-15.

Ellies, D. L., Viviano, B., McCarthy, J., Rey, J. P., Itasaki, N., Saunders, S., Krumlauf, R. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J Bone Miner Res, 2006 Nov;21 (11), 1738-49.

Vachharajani A, Bethin K, Mouillet JF, Sadovsky Y, Saunders S. The rare occurrence of absent adrenals in a term infant: a case report and review of the literature. Am J Perinatol. 2006 Feb;23(2):111-4. Review.

Vachharajani A, Saunders S. Allelic variation in the serotonin transporter (5HTT) gene contributes to idiopathic pulmonary hypertension in children. Biochem Biophys Res Commun. 2005 Aug 26;334(2):376-9.

Viviano BL, Silverstein L, Pflederer C, Paine-Saunders S, Mills K, Saunders S. Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. Dev Biol. 2005 Jun 1;282(1):152-62.

Viviano BL, Paine-Saunders S, Gasiunas N, Gallagher J, Saunders S. Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin. J Biol Chem. 2004 Feb 13;279(7):5604-11. Epub 2003 Nov 25.

Paine-Saunders S, Viviano BL, Economides AN, Saunders S. Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients. J Biol Chem. 2002 Jan 18;277(3):2089-96. Epub 2001 Nov 12.

DeBaun MR, Ess J, Saunders S. Simpson Golabi Behmel syndrome: progress toward understanding the molecular basis for overgrowth, malformation, and cancer predisposition. Mol Genet Metab. 2001 Apr;72(4):279-86. Review.

Paine-Saunders S, Viviano BL, Zupicich J, Skarnes WC, Saunders S. glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol. 2000 Sep 1;225(1):179-87.

Paine-Saunders S, Viviano BL, Saunders S. GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13. Genomics. 1999 May 1;57(3):455-8.

More articles and abstracts by Scott Saunders, MD

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Copyright 2015 Washington University School of Medicine