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Yvette I. Sheline, MD

Current Position
Professor, Psychiatry
Professor, Radiology
Professor, Neurology

Specialty Areas

Patients Seen At
Barnes-Jewish Hospital (south) - Renard Hospital Building
4940 Children's Place, Room 1115
St. Louis, MO  63110
Fax:   314-362-7599
View Campus Map   View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Psychiatry
660 South Euclid Avenue, Campus Box: 8134
St. Louis, MO  63110

Areas of Clinical Interest
Depression, treatment resistant depression and dementia.

Board Certification
Psychiatry -- Certified
Geriatric Psychiatry -- Added Qualification

This physician is not able to accept new patients at this time.

Medical Education
B.A.: Biology, Harvard College, Cambridge, Massachusetts, 1974
M.S.: Neurophysiology, Yale University, New Haven, Connecticut, 1975
Medical Degree: Boston University, Boston, Massachusetts, 1979
Residency: Psychiatry, Harvard University at Beth Israel Hospital, Boston, Massachusetts, 1983
Hospital Affiliations
Barnes-Jewish Hospital

Honors and Awards
Listed in Best Doctors in America, 2009-2013 (Best Doctors, Inc.)
NIH-Mid –Career Investigator Award in Clinical Research, 2007-2012
NIH Mid-Career Investigator Award in Clinical Research, 2002-2007
NIMH Academic Career Development Award (KO7), 1996

Editorial Responsibilities

American Journal of Geriatric Psychiatry
American Journal of Psychiatry
Archives of General Psychiatry
Biological Psychiatry

Book Chapters
Sheline, YI Brain Structural Changes Associated with Depression In Gilliam F, Sheline YI, Kanner A. (eds) Depression and Brain Dysfunction, Parthenon Publishing, Oxon, UK, 2005

Sheline YI, Mintun MA. Structural and Functional Imaging Studies in Affective Disorders. In Neuropsychopharmacology; Fifth Generation of Progress, J. Coyle, D. Charney, K. Davis, C. Nemeroff (eds). Raven Press, 2001

Selected Publications
Sheline YI, Barch DM, Price JL, Rundlge MM, Vaishnavi SN, Snyder AZ, Mintun MA, Wang S, Coalson RS, Raichle, ME. The default mode network and self-referential processes in depression. Proc Natl Acad Sci, 106:1942-7, 2009.

Fales CL, Barch DM, Rundle MM, Mintun MA, Mathews J, Snyder AZ, Sheline YI. Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression. J Affect Disord, 112:2006-11, 2009.

Fales CL, Barch DM, Rundle MM, Mintun MA., Snyder AZ., Cohen JD, Mathews J, Sheline YI. Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression. Biol Psychiatry, 162:39-49, 2008.

Sheline YI, Price JL, Vaishnavi SN, Mintun MA, Barch DM, Epstein AA, Wilkins CH, Snyder AZ, Couture L, Schechtmank, McKinstry RC. Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors. AM J Psychiatry, 165:524-32, 2008.

Sheline YI, Barch DM, Garcia K, Gersing K, Pieper C, Welsh-Bohmer K, Steffens DC, Doraiswamy PM. Cognitive Function in Late Life Depression: Relationships to Depression Severity, Cerebrovascular Risk Factors and Processing Speed. Biol Psychiatry, 60:58-65, 2006.

Buckner RL, Snyder AZ, Shannon BJ, LaRossa G, Sachs R, Fotenos AF, Sheline YI, Klunk WE, Mathis CA, Morris JC, Mintun MA. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci, 25:7709-7717, 2005.

Sheline YI. Neuroimaging Studies of Mood Disorder Effects on the Brain. Biol Psychiatry, 54:338-352, 2003.

Sheline Y, Gado M, Kraemer H. Untreated Depression and Hippocampal Volume loss. Am J Psych, 160:1516-1518, 2003.

Sheline YI, Sanghavi M, Mintun MA, Gado MH: Depression duration but not age predicts hippocampal volume loss in women with recurrent major depression. J Neurosci, 19:5034-5043, 1999.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Yvette I. Sheline

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Copyright 2014 Washington University School of Medicine