Wayne M. Yokoyama, MD
Current Position
Professor, Medicine
Division of Rheumatology
Professor, Pathology and Immunology
Sam J. Levin and Audrey Loew Levin Chair for Research on Arthritis
Investigator, Howard Hughes Medical Institute
Director, Medical Scientist Training Program
Specialty Areas
Rheumatology
Internal Medicine
Mailing Address
|
Washington University School of Medicine
Division of Rheumatology
660 South Euclid Avenue, Campus Box 8045
St. Louis,
MO
63110
|
Areas of Clinical Interest
Human immunology, natural killer cells
NOT SEEING CLINIC PATIENTS AT THIS TIME
Board Certification
Internal Medicine
--
Certified
Rheumatology
--
Certified
Medical Education
B.A.: University of Rochester, Rochester, New York, 1974
Medical Degree: University Of Hawaii at Manoa, Honolulu, Hawaii, 1978
Residency: Internal Medicine, University of Iowa Hospitals, Iowa City, Iowa, 1981
Fellowship: Clinical, Rheumatology, University of Iowa Hopsitals, Iowa City, Iowa, 1982
Fellowship: Research, Rheumatology, University of Iowa Hospitals, Iowa City, Iowa, 1985
Fellowship: Research, Immunology, NIAID, NIH, Bethesda, Maryland, 1989
Hospital Affiliations
Barnes-Jewish Hospital
Honors and Awards
Listed in Best Doctors in America, 2009-2013 (Best Doctors, Inc.)
Carl and Gerty Cori Faculty Achievement Award, 2011
American Academy of Arts and Sciences, elected, 2009
National Academy of Sciences, elected, 2007
Association of American Physicians (AAP), elected, 2000
American Society for Clinical Investigation (ASCI), elected, 1996
Editorial Responsibilities
Transmitting Editor
International Immunology
Editorial Board
Immunogenetics
Immunity
Immunology and Cell Biology
Associate Editor
Annual Review of Immunology
Books and Book Chapters
Paul WE, Littman DR and Yokoyama WM. (Eds.) Annual Review of Immunology Vol. 28, Annual Reviews, Inc. Palo Alto, 2010, in press
Paul WE, Littman, DR and Yokoyama WM. (Eds.) Annual Review of Immunology Vol. 27, Annual Reviews, Inc. Palo Alto, 2009, 762pp
Yokoyama WM. Chapter 17. Natural killer cells. (Paul, WE, Ed.) Fundamental Immunology (Sixth Edition), Lippincott-Raven, New York. 2008; pg 483-517
Review Articles
Jonsson AH, and Yokoyama WM. Natural killer cell tolerance: Licensing and other mechanisms. Adv Immunol 2009; 101:27-79
Scalzo AA, and Yokoyama WM. Cmv1 and natural killer cell responses to murine cytomegalovirus infection. Curr Top Immuno Microbio 2008; 321:101-122
Yokoyama WM. Mistaken notions about natural killer cells. Nature Immunol 2008; 9:481-485
Selected Publications
Byun M, Verweij MC, Pickup DJ, Wiertz EJHJ, Hansen TH, and Yokoyama WM. Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells. Cell Host Microbe 2009; 6:422-432. PMCID: PMC2791900
Cooper MA, Elliott JM, Keyel PA, Yang L, Carrero JA, and Yokoyama WM. Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci (USA) 2009; 106:1915-1919. PMCID: PMC2644138
Sunwoo JB, Kim S, Yang L, Naik T, Higuchi DA, Rubenstein JL, and Yokoyama WM. Distal-less homeobox transcription factors regulate development and maturation of natural killer cells. Proc Natl Acad Sci (USA) 2008; 105:10877-10882. PMCID: PMC2504821
Tripathy SK, Keyel PA, Yang L, Pingel JT, Cheng TP, Schneeberger A, and Yokoyama WM. Continuous engagement of self-specific activation receptors induces NK cell tolerance. J Exp Med 2008; 205:1829-1841. PMCID: PMC2525593
Kim S, Sunwoo JB, Yang L, Choi T, Song Y-J, French, AR, Vlahiotis A, Piccirillo JF, Cella M, Colonna M, Mohanakumar T, Hsu KC, Dupont B, and Yokoyama WM. HLA alleles determine differences in human natural killer cell responsiveness and potency. Proc Natl Acad Sci (USA) 2008; 105:3053-3058. PMCID: PMC2268583
Byun M, Wang X, Pak M, Hansen TH, and Yokoyama WM. Cowpox virus exploits KDEL retrieval pathway to evade MHC class I biosynthesis. Cell Host Microbe 2007; 2:306-315
Kim S, Poursine-Laurent J, Truscott SM, Lybarger L, Song Y-J, Yang L, French AR, Sunwoo JB, Lemieux S, Hansen TH, and Yokoyama WM. Licensing of natural killer cells by host MHC class I. Nature 2005; 436:709-713
For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Yokoyama