Internal Medicine / Pulmonary and Critical Care Medicine

The Washington University physicians in the Department of Internal Medicine encompass 14 specialty clinical divisions.

Over 270 physicians in the department of medicine treat patients with a wide range of diseases, disorders and conditions.

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Mario Castro, MD, MPH

Specialty Areas
Asthma
Pulmonary Disease
Lung Cancer

Areas of Clinical Interest
Asthma and related allergic disease, COPD, emphysema, chronic bronchitis, Interstital lung disease, Idiopathic pulmonary fibrosis, sarcoidosis, chronic cough, unexplained shortness of breath, vasculitis, chronic lung infections, pulmonary hypertension, bronchiectasis.

Major or Recent Publications/Awards

Honors and Awards

Listed in Best Doctors in America, 2003, 2005, 2006, 2008 (Best Doctors, Inc)

Humanitarian Recognition Award, The CHEST Foundation, 2005

Books and Book Chapters

Aysola R, Castro M. The goals of asthma management - short and long term goals; In: Clinical Asthma. Philadelphia, PA: Elsiever, 2008

Lugogo N, Kraft M, Castro M. Epidemiology of Asthma; In: Clinical Asthma. Philadelphia: Elsiever, 2008

Castro M, Draft M, Eds. Clinical Asthma, Philadelphia: Elsiever, 2008

Aysola R, Castro M. Status Asthmaticus; In: The Washington Manual of Critical Care, Philadelphia: Lippincott Williams & Wilkins, 2008

Shifren A, Cohen L, Castro M. Asthma. In: The Washington Manual Pulmonary Medicine Subspecialty Consult, Philadelphia: Lippincott, Williams & Wilkins, 2006

Selected Journal Articles

Randolph AG, Weiss ST, Graham DA, Patel K, Black W. Castro M. Development of asthma after hospitalization for respiratory syncytial virus bronchiolitis in early life. J Allergy Clin Immunol. In Press

Lara A, Khatri SB, Wang Z, Comhair SAA, Xu W, Dweik RA, Bodine M, Levisin BS, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Gaston B, Israel E, Jarjour N, Moore W, Peters SP, Teague WG, Wenzel S, Hazen SL, Erzurum SC, for the National Heart Lung Blood Institute Severe Asthma Research Program (SARP). Alterations of the Arginine Metabolome in Asthma. Am J Resp Crit Care Med. In Press

Aysola R, Hoffman EA, Gierada D, Wenzel S, Cook-Granroth J, Tarsi J, Schechtman K, Ramkumar T, Newell J, Fain S, Altes TA, Castro M, or the NHLBI Severe Asthma Research Program (SARP). Airway remodeling measured by MDCT is increased in severe asthma and correlates with pathology. CHEST. In Press

Jennings JE, Ramkumar T, Jingnan M, Boyd J, Castro M, Field JJ, Strunk RC, DeBaun MR. Elevated urinary leukotriene E4 levels are associated with hospitalization for pain in children with sickle cell disease. Am J Hematology. In Press

Kim EY, Battaile JT, Patel AC, You Y, Agapov E, Grayson MH, Alevy Y, Tucker J, Swanson S, Tyner JW, Morton JD, Castro M, Polenini D, Patterson GA, Schwendener RA, Allard JD, Peltz G, and Holtzman MJ. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nature Medicine 2008:14(6):633-640

Bailey W, Castro M, Matz J, White M, Dransfield M, Yancey S, Ortega H. Asthma exacerbations in Africian Americans treated for 1 year with combination fluticasone propionate and salmeterol or fluticasone propionate alone. Cur Med Res Opin 2008:24(6):1669-1682

Lima JJ, Mohapatra S, Feng H, Lockey R, Jena PK, Castro M, Irvin C, Johnson JA, Wang J, Sylvester JE. A polymorphism in the NPPA gene associates with asthma. Clin Exp All 2008; 38:1117-1123

Sorkness RL, Bleecker ER, Busse WW, Curran-Everett D, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Gaston BM, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Wenzel SE, for the NHLBI Severe Asthma Research Program (SARP). Lung Function in Adults with Stable but Severe Asthma: Air Trapping and Incomplete Reversal of Obstruction with Bronchodilation. J Appl Physiol 2008: 104:394-403

Brasier AR, Victor S, Boetticher G, Ju H, Lee C, Bleecker ER, Castro M, Busse WW, Calhoun WJ. Molecular phenotyping of severe asthma: Informative cytokine patterns in bronchoalveolar lavage. J Allergy Clin Immunol 2008: 121:30-7

Moonie S, Sterling DA, Figgs LW, Castro M. The relationship between school absence, academic performance and asthma status. J School Health 2008, 78(3):140-148

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Mario Castro