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Internal Medicine / Pulmonary and Critical Care Medicine

Mario Castro, MD, MPH, FCCP

Current Position
Professor, Medicine and Pediatrics
Division of Pulmonary and Critical Care Medicine

Specialty Areas
Pulmonary Disease
Lung Cancer

Additional Features & Interviews with Dr. Castro:

Your Health Update:  A Study for Easier Breathing and Fewer Asthma Medications

Patients Seen At
Center for Advanced Medicine
Lung Center
4921 Parkview Place, B, 8
St. Louis, MO  63110
View Floor Map  View Campus Map   View Driving Directions

Mailing Address
Washington University School of Medicine
Division of Pulmonary and Critical Care Medicine
660 South Euclid Avenue, Campus Box 8052
St. Louis, MO  63110

Areas of Clinical Interest
Asthma and related allergic disease, COPD, emphysema, chronic bronchitis, interstital lung disease, idiopathic pulmonary fibrosis, sarcoidosis, chronic cough, unexplained shortness of breath, vasculitis, chronic lung infections, pulmonary hypertension, bronchiectasis.

Board Certification
Pulmonary Disease -- Certified
Internal Medicine -- Certified
Critical Care Medicine -- Certified

Medical Education
Medical Degree: University Of Missouri, Kansas City, Missouri, 1988
Residency: Internal Medicine, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota, 1991
Fellowship: Pulmonary/Critical Care, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota, 1994
Graduate: Public Health, St. Louis University School of Public Health, St. Louis, Missouri, 1998
Hospital Affiliations
Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Honors and Awards
Listed in Best Doctors in America, 2003-2013 (Best Doctors, Inc.)
President, American Lung Association of Missouri, 2003-2005

Disclosure of Financial Interests with Industry
Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

Dr. Mario Castro reported the following earned financial interests during calendar year 2014. Move your mouse over a header for more info.
Royalties: When a faculty member invents or conceives a new or improved process or product, the company that manufactures the product will make royalty payments to the faculty member. Royalty payments usually are a small percentage of the company’s revenue related to that product.
Equity: Equity is an ownership interest in a company. Faculty members may be paid for their service to a company in stock or the option to obtain stock.
Consulting &
Advisory Boards
Consulting and Advisory Boards: Faculty may be paid to provide expertise to a company by being their consultant, or by serving on an advisory board.
Speaker Fees
Speaker Fees: Companies may pay faculty to speak to professional audiences about their products.
Genentech    $25,001-$50,000 
Advanced Health Media    $10,001-$25,000 
Sparo  Yes   
To learn more about Washington University's policies on collaborations with industry, click here.

Editorial Responsibilities
Ad hoc Reviewer 1994 - present:
American Journal Respiratory Cell Molecular Biology
American Journal Respiratory Critical Care Medicine
European Respiratory Journal
Journal of Allergy Clinical Immunology
CHEST; Mayo Clinic Proceedings
New England Journal of Medicine
Journal of Rheumatology
Liver Transplant and Surgery, Respiratory Medicine
Associate Editor: The Year Book of Pulmonary Disease, 1998-2001
Editor: Clinical Asthma, 2008, Philadelphia: Elsiever, 2008.

Selected or Recent Journal Articles

Sumino K, Castro M. Bronchial thermoplasty: safe for our severe asthma patients? Ann Allergy Asthma Immunol. 2013 Nov;111(5):311-2.

Sheshadri A, Castro M, Chen A. Bronchial thermoplasty: a novel therapy for severe asthma. Clin Chest Med. 2013 Sep;34(3):437-44.

Parulekar AD, Boomer JS, Patterson BM, Yin-Declue H, Deppong CM, Wilson BS, Jarjour NN, Castro M, Green JM. A randomized controlled trial to evaluate inhibition of T-cell costimulation in allergen-induced airway inflammation. Am J Respir Crit Care Med. 2013 Mar 1;187(5):494-501.

Sumino K, Sugar EA, Irvin CG, Kaminsky DA, Shade D, Wei CY, Holbrook JT, Wise RA, Castro M; American Lung Association Asthma Clinical Research Centers. Methacholine challenge test: diagnostic characteristics in asthmatic patients receiving controller medications. J Allergy Clin Immunol. 2012 Jul;130(1):69-75.e6. doi: 10.1016/j.jaci.2012.02.025. Epub 2012 Apr 1. Erratum in: J Allergy Clin Immunol. 2012 Nov;130(5):1084.

Bacharier LB, Cohen R, Schweiger T, Yin-Declue H, Christie C, Zheng J, Schechtman KB, Strunk RC, Castro M. Determinants of asthma after severe respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol. 2012 Jul;130(1):91-100.e3.

Liu M, Subramanian V, Christie C, Castro M, Mohanakumar T. Immune responses to self-antigens in asthma patients: clinical and immunopathological implications. Hum Immunol. 2012 May;73(5):511-6.

Shifren A, Witt C, Christie C, Castro M. Mechanisms of remodeling in asthmatic airways. J Allergy (Cairo). 2012;2012:316049.

Castro M, Mathur S, Hargreave F, Boulet LP, Xie F, Young J, Wilkins HJ, Henkel T, Nair P; Res-5-0010 Study Group. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2011 Nov 15;184(10):1125-32.

Castro M, Fain SB, Hoffman EA, Gierada DS, Erzurum SC, Wenzel S; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Lung imaging in asthmatic patients: the picture is clearer. J Allergy Clin Immunol. 2011 Sep;128(3):467-78.

Castro M, Rubin A, Laviolette M, Hanania NA, Armstrong B, Cox G; AIR2 Trial Study Group. Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma. Ann Allergy Asthma Immunol. 2011 Jul;107(1):65-70.

Rodrigues J, de Castro M, Balakrishnan N, Cancho VG. Destructive weighted Poisson cure rate models. Lifetime Data Anal. 2011 Jul;17(3):333-46.

Castro M, Musani AI, Mayse ML, Shargill NS. Bronchial thermoplasty: a novel technique in the treatment of severe asthma. Ther Adv Respir Dis. 2010 Apr;4(2):101-16.

Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Shargill NS, Quiring J, Berry SM, Cox G; AIR2 Trial Study Group. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010 Jan 15;181(2):116-24.

Carlstrom L, Castro M. Severe asthma: what makes it so hard to manage? Curr Allergy Asthma Rep. 2009 Sep;9(5):393-400. Review.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Mario Castro.

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Copyright 2015 Washington University School of Medicine