Alzheimer's Disease
Major or Recent Publications/Awards
Honors and Awards
MetLife Award for research on Alzheimer's disease, 2006
MERIT award, National Institute on Aging, 2004
Elected member, American Society for Clinical Investigation, 2004
Potamkin Prize for research on Alzheimer's disease, 2003
Elected member, American Neurological Association, 1997
Paul Beeson Physician /Faculty Scholar Award, American Federation Research (AFAR), 1995
Selected Publications
Rapid microglial response around amyloid pathology after systemic anti-Abeta
antibody administration in PDAPP mice. Koenigsknecht-Talboo J, Meyer-Luehmann
M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman
DM. J Neurosci. 2008 Dec 24;28(52):14156-64. PMID: 19109498 [PubMed - indexed
for MEDLINE]
Cerebrovascular dysfunction in amyloid precursor protein transgenic mice:
contribution of soluble and insoluble amyloid-beta peptide, partial restoration
via gamma-secretase inhibition.
Han BH, Zhou ML, Abousaleh F, Brendza RP,
Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel
GJ. J Neurosci. 2008 Dec 10;28(50):13542-50. PMID: 19074028 [PubMed - indexed
for MEDLINE]
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse
brain. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM,
Zlokovic BV. J Clin Invest. 2008 Dec;118(12):4002-13. doi: 10.1172/JCI36663.
Epub 2008 Nov 13. PMID: 19033669 [PubMed - indexed for MEDLINE]
Biomarkers of Alzheimer's disease. Craig-Schapiro R, Fagan AM, Holtzman DM.
Neurobiol Dis. 2008 Oct 28. [Epub ahead of print] PMID: 19010417 [PubMed - as
supplied by publisher]
The low density lipoprotein receptor-related protein 1 mediates uptake of
amyloid beta peptides in an in vitro model of the blood-brain barrier cells.
Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu
G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. J Biol Chem. 2008
Dec 12;283(50):34554-62. Epub 2008 Oct 21. PMID: 18940800 [PubMed - indexed for
MEDLINE]
Alzheimer's disease risk variants show association with cerebrospinal fluid
amyloid beta. Kauwe JS, Wang J, Mayo K, Morris JC, Fagan AM, Holtzman DM, Goate
AM. Neurogenetics. 2009 Feb;10(1):13-7. Epub 2008 Sep 24. PMID: 18813964 [PubMed
- in process]
Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's
disease. Cheng H, Zhou Y, Holtzman DM, Han X. Neurobiol Aging. 2008 Aug 30.
[Epub ahead of print] PMID: 18762354 [PubMed - as supplied by publisher]
Amyloid-beta dynamics correlate with neurological status in the injured human
brain. Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N,
Zipfel GJ, Holtzman DM. Science. 2008 Aug 29;321(5893):1221-4. PMID: 18755980
[PubMed - indexed for MEDLINE]
Ceramide is responsible for the failure of compensatory nerve sprouting in
apolipoprotein E knock-out mice. Maysinger D, Holmes M, Han X, Epand RM, Pertens
E, Foerster A, Barlas C, Holtzman DM, Diamond J. J Neurosci. 2008 Jul
30;28(31):7891-9. PMID: 18667621 [PubMed - indexed for MEDLINE]
Alzheimer's disease: Moving towards a vaccine. Holtzman DM. Nature. 2008 Jul
24;454(7203):418-20. No abstract available. PMID: 18650906 [PubMed - indexed for
MEDLINE]
ApoE promotes the proteolytic degradation of Abeta. Jiang Q, Lee CY,
Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM,
Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz
P, Landreth GE. Neuron. 2008 Jun 12;58(5):681-93. PMID: 18549781 [PubMed -
indexed for MEDLINE]
Variation in MAPT is associated with cerebrospinal fluid tau levels in the
presence of amyloid-beta deposition. Kauwe JS, Cruchaga C, Mayo K, Fenoglio
C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Morris JC, Fagan AM,
Holtzman DM, Goate AM. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8050-4.
Epub 2008 Jun 9. PMID: 18541914 [PubMed - indexed for MEDLINE]
Early diffusion-weighted MRI as a predictor of caspase-3 activation after
hypoxic-ischemic insult in neonatal rodents. Wendland MF, Faustino J, West T,
Manabat C, Holtzman DM, Vexler ZS. Stroke. 2008 Jun;39(6):1862-8. Epub 2008 Apr
17. PMID: 18420950 [PubMed - indexed for MEDLINE]
Endocytosis is required for synaptic activity-dependent release of
amyloid-beta in vivo.
Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK,
Silverio LM, Bu G, Mennerick S, Holtzman DM. Neuron. 2008 Apr
10;58(1):42-51. PMID: 18400162 [PubMed - indexed for MEDLINE]
Active and passive immunotherapy for neurodegenerative disorders. Brody DL,
Holtzman DM. Annu Rev Neurosci. 2008;31:175-93. Review. PMID: 18352830 [PubMed -
indexed for MEDLINE]
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model
of Alzheimer's disease. Meyer-Luehmann M, Spires-Jones TL, Prada C,
Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM,
Bacskai BJ, Hyman BT. Nature. 2008 Feb 7;451(7179):720-4. PMID: 18256671 [PubMed
- indexed for MEDLINE]
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model
of Alzheimer disease. Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten
A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM. J
Clin Invest. 2008 Feb;118(2):671-82. PMID: 18202749 [PubMed - indexed for
MEDLINE]
Neuropathology for the neuroradiologist: plaques and tangles. Wippold FJ 2nd,
Cairns N, Vo K, Holtzman DM, Morris JC. AJNR Am J Neuroradiol. 2008
Jan;29(1):18-22. Epub 2007 Oct 9. Review. PMID: 17925367 [PubMed - indexed for
MEDLINE]
Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM. Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity.Proc Natl Acad Sci U S A. 2007;Jun 19;104(25):10673-8.
Bateman RJ, Wen G, Morris JC, Holtzman DM. Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker. Neurology. 2007; Feb 27;68(9):666-9.
Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol. 2007; Mar;64(3):343-9.
Bateman RJ, Munsell LY, Morris JC, Swarm R, Yarasheski KE, Holtzman DM. Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med. 2006; Jul;12(7):856-61. Epub 2006 Jun 25.
Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, LaRossa GN, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol. 2006; Mar;59(3):512-9.
West T, Atzeva M, Holtzman DM. Caspase-3 deficiency during development increases vulnerability to hypoxic-ischemic injury through caspase-3-independent pathways. Neurobiol Dis 2006; 22(3):523-37.
Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 2005; 48(6):913-922.
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer's disease mouse model. J. Clin. Invest. 2005; 115: 3285 - 3290.
Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer's disease Journal of Biological Chemistry 2005; 280(52):43236-43242.
Hu Y, Townsend RR, Fagan AM, Holtzman DM. Comparative proteomic analysis of intra- and inter-individual variation in human cerebrospinal fluid. Molecular and Cellular Proteomics 2005; 4(12):2000-9.
Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, Holtzman DM. Treatment with an amyloid-b antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease Journal of Neuroscience 2005;25: 6213- 6220.
Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. Journal of Neuroscience 2005; 25:2803-2810.
Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti- Ab antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. J Clin Invest. 2005; 115: 428-433.
Wahrle, SE, Jiang H, Parsadanian M, Legleiter J, Han X, Fryer JD, Kowalewski T and Holtzman, DM. ABCA1 is required for normal CNS apoE levels and for lipidation of astrocyte-secreted apoE. Journal of Biological Chemistry 2004; 279(39):40987-20993.
DeMattos R, Cirrito J, O'Dell M, Taylor J, Harmony J, Aronow B, Bales K, Paul S, Holtzman DM. ApoE and clusterin cooperative suppress Abeta levels and deposition: Evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron 2004; 41:193-202.
Cirrito JR, May PC, O'Dell MA, Taylor JW, Parsadanian M, Cramer JW, Audia JE, Nissen JS, Bales KR, Paul SM, DeMattos RB, Holtzman DM. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-b metabolism and half-life. Journal of Neuroscience 2003; 23:8844-8853.
Fryer JD, Taylor JW, DeMattos RB, Bales KR, Paul SM, Parsadanian M, Holtzman DM. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in APP transgenic mice. Journal of Neuroscience 2003; 23: 7889-7896.
DeMattos RB, O'Dell MA, Parsadanian M, Taylor JW, Harmony JAK, Bales KR, Paul SM, Aronow BJ, Holtzman DM. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2002; 99:10843-10848. (10.1073/pnas.162228299)
For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. David H. Holtzman